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A novel immunomodulatory hemocyanin from the limpet Fissurella latimarginata promotes potent anti-tumor activity in melanoma
(Public Library of Science, 2014)
Hemocyanins, the huge oxygen-transporting glycoproteins of some mollusks, are used as immunomodulatory proteins with proven anti-cancer properties. The biodiversity of hemocyanins has promoted interest in identifying new ...
The oxygen binding properties of hemocyanin from the mollusk Concholepas concholepas
(Elsevier, 2017)
Hemocyanins have highly conserved copper-containing active sites that bind oxygen. However, structural differences
among the hemocyanins of various mollusks may affect their physicochemical properties. Here, we
studied ...
A three-barrier model for the hemocyanin channel
(1981)
Keyhole limpet hemocyanin forms ion-conducting channels in planar lipid bilayer membranes. Ionic current through the open hemocyanin channel presents the following characteristics: (a) it is carried mainly by cations; (b) ...
Experimental Guillain-Barre syndrome induced by immunization with gangliosides: Keyhole limpet hemocyanin is required for disease triggering
(Elsevier Science, 2017-06)
An experimental model of Guillain-Barré Syndrome has been established in recent years. Rabbits develop disease upon immunization with a single dose of an emulsion containing bovine brain gangliosides, KLH and complete ...
Hemocyanin of the caenogastropod Pomacea canaliculata exhibits evolutionary differences among gastropod clades
(Public Library of Science, 2020-01-30)
Structural knowledge of gastropod hemocyanins is scarce. To better understand their evolution and diversity we studied the hemocyanin of a caenogastropod, Pomacea canaliculata (PcH). Through a proteomic and genomic approach, ...
The oxygen-binding properties of hemocyanin from the mollusk Concholepas concholepas
(2017)
Hemocyanins have highly conserved copper-containing active sites that bind oxygen. However, structural differences among the hemocyanins of various mollusks may affect their physicochemical properties. Here, we studied the ...
Antitumor activity and carrier properties of novel hemocyanins coupled to a mimotope of GD2 ganglioside
(Elsevier, 2018-04-25)
Conjugation to carrier proteins is a way to improve the immunogenicity of peptides. Such is the case for peptides mimicking carbohydrate tumor-associated antigens in cancer vaccine development. The most used protein for ...
Antitumor activity and carrier properties of novel hemocyanins coupled to a mimotope of GD2 ganglioside
(2018)
Conjugation to carrier proteins is a way to improve the immunogenicity of peptides. Such is the case for peptides mimicking carbohydrate tumor-associated antigens in cancer vaccine development. The most used protein for ...