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The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection
(Public Library Of Science, 2014-09)
Despite their abundance at gastrointestinal sites, little is known about the role of galectins in gut immune responses. We have therefore investigated the Citrobacter rodentium model of colonic infection and inflammation ...
Galectins: structure, function and therapeutic potential
(Cambridge University Press, 2008-10)
Galectins are a family of animal lectins that bind beta-galactosides. Outside the cell, galectins bind to cell-surface and extracellular matrix glycans and thereby affect a variety of cellular processes. However, galectins ...
An integrated computational analysis of the structure, dynamics, and ligand binding interactions of the human galectin network
(American Chemical Society, 2011-08)
Galectins, a family of evolutionarily conserved animal lectins, have been shown to modulate signaling processes leading to inflammation, apoptosis, immunoregulation, and angiogenesis through their ability to interact with ...
Galectins and microenvironmental niches during hematopoiesis
(Lippincott Williams, 2011-11)
Galectins, a family of evolutionarily conserved glycan-binding proteins, are involved in the regulation of multiple cellular processes (e.g. immunity, apoptosis, cellular signaling, development, angiogenesis and cellular ...
Spatial expression of two anti-inflammatory mediators, annexin 1 and galectin-1, in nasal polyposis
(Blackwell Publishing, 2006-10-01)
Background There is renewed interest in the role played by specific counter-regulatory mechanisms to control the inflammatory host response, poorly investigated in human pathology. Here, we monitored the expression of two ...
Galectins as immunoregulators during infectious processes: from microbial invasion to the resolution of the disease
(Wiley Blackwell Publishing, Inc, 2005-05-22)
Recent evidence has implicated galectins, a family of evolutionarily conserved carbohydrate-binding proteins, as regulators of immune cell homeostasis and host-pathogen interactions. Galectins operate at different levels ...
Galectins: New agonists of platelet activation
(Walter de Gruyter & Co, 2013-03-18)
Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug and is crucial for hemostasis. However, uncontrolled platelet activation may lead to the formation of occlusive thrombi. Several ...
Galectins: new agonists of platelet activation
(De Gruyter, 2013-07)
Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug and is crucial for hemostasis. However, uncontrolled platelet activation may lead to the formation of occlusive thrombi. Several ...
Antibodies against galectin-8 in patients with systemic lupus erythematosus
(SOC MEDICA SANTIAGO, 2006)
Background: The family of lectins known as galectins (galectins 1-14) are involved in the regulation of the immune system and in oncogenesis. During a search for antigens recognized by antibodies produced by a patient with ...