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Alzheimer's disease: A review from the pathophysiology to diagnosis, new perspectives for pharmacological treatment
(2018-01-01)
Dementia is characterized by the impairment of cognition and behavior of people over 65 years. Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the world, as approximately 47 million people are ...
PSEN1 and PSEN2 Gene Expression in Alzheimer's Disease Brain: A New Approach
(Ios Press, 2014-01-01)
Presenilin 1 (PSEN1) and presenilin 2 (PSEN2) genes encode the major component of y-secretase, which is responsible for sequential proteolytic cleavages of amyloid precursor proteins and the subsequent formation of ...
ApoER2 expression increases AB production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of Y-secretase activity
(2007)
Abstract
Background
The generation of the amyloid-β peptide (Aβ) through the proteolytic processing of the amyloid precursor protein (APP) is a central event in the pathogenesis ...
TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intracellular domain
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2007)
Neurotrophins are trophic factors that regulate important neuronal functions. They bind two unrelated receptors, the Trk family of receptor-tyrosine kinases and the p75 neurotrophin receptor (p75). p75 was recently identified ...