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Complex networks: the key to systems biology
(Sociedade Brasileira de Genética, 2008)
Though introduced recently, complex networks research has grown steadily because of its potential to represent, characterize and model a wide range of intricate natural systems and phenomena. Because of the intrinsic ...
Controllability of protein-protein interaction phosphorylation-based networks: Participation of the hub 14-3-3 protein family
(Nature Publishing Group, 2016-05)
Posttranslational regulation of protein function is an ubiquitous mechanism in eukaryotic cells. Here, we analyzed biological properties of nodes and edges of a human protein-protein interaction phosphorylation-based ...
Mechanisms, regulation and functions of the unfolded protein response
(Nature, 2020)
The unfolded protein response (UPR) comprises a network of signalling pathways that reprogramme transcription, translation and protein modifications to relieve the load of unfolded or misfolded proteins in the endoplasmic ...
Integrative meta-analysis identifies microRNA-regulated networks in infantile hemangioma
(2016-01-15)
Background: Hemangioma is a common benign tumor in the childhood; however our knowledge about the molecular mechanisms of hemangioma development and progression are still limited. Currently, microRNAs (miRNAs) have been ...
CALI: a novel model for visual mining of biological relevant patterns in protein-ligand graphs
(Universidade Federal de Minas GeraisBrasilICX - DEPARTAMENTO DE CIÊNCIA DA COMPUTAÇÃOPrograma de Pós-Graduação em Ciência da ComputaçãoUFMG, 2016-10-27)
Protein-ligand interaction (PLI) networks show how proteins interact with small nonprotein
ligands and can be used to study molecular recognition, which plays an important
role in biological systems. The binding and ...
The Protein Interactome Of Collapsin Response Mediator Protein-2 (crmp2/dpysl2) Reveals Novel Partner Proteins In Brain Tissue
(WILEY-V C H VERLAG GMBHWEINHEIM, 2015)
The fragility of protein-protein interaction networks
(2011)
The capacity to resist perturbations from the environment is crucial to the survival of all organisms. We quantitatively analyze the susceptibility of protein interaction networks of numerous organisms to random and targeted ...
The role of protein disorder in the 14-3-3 interaction network
(Royal Society of Chemistry, 2012-11)
Disordered regions are segments of a protein that do not fold completely and thus remain flexible. These regions have key physiological roles, particularly in phospho-proteins, which are enriched in disorder-promoting ...