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Light perception and signalling by phytochrome A
(Oxford University Press, 2014-06)
In etiolated seedlings, phytochrome A (phyA) mediates very-low-fluence responses (VLFRs), which initiate de-etiolation at the interphase between the soil and above-ground environments, and high-irradiance responses (HIR), ...
DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes
(NATURE PUBLISHING GROUPLONDON, 2012)
Recurrent chromosomal translocations underlie both haematopoietic and solid tumours. Their origin has been ascribed to selection of random rearrangements, targeted DNA damage, or frequent nuclear interactions between ...
Nuclear localization of heme oxygenase-1 in pathophysiological conditions: Does it explain the dual role in cancer?
(Multidisciplinary Digital Publishing Institute, 2021-01)
Heme Oxygenase-1 (HO-1) is a type II detoxifying enzyme that catalyzes the rate-limiting step in heme degradation leading to the formation of equimolar quantities of carbon monoxide (CO), free iron and biliverdin. HO-1 was ...
Estudo da cinética da translocação do fator de crescimento epidermal (EGF) para o núcleo e da sua localização subnuclear em células-tronco mesenquimais e em células tumorais da linhagem SK-HEP-1
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAPrograma de Pós-Graduação em Bioquímica e ImunologiaUFMG, 2017-02-23)
By interacting with its receptor (EGFR), epidermal growth factor (EGF) activates cell signaling pathways involving proliferation, migration, differentiation and tumourigenesis. This receptor can be found in cell nucleus, ...
Thyroid hormone-induced cytosol-to-nuclear translocation of rat liver Nrf2 is dependent on Kupffer cell functioning
(2012)
L-3,3′,5-triiodothyronine (T3) administration upregulates nuclear factor-E2-related factor 2 (Nrf2) in rat liver, which is redox-sensitive transcription factor mediating cytoprotection. In this work, we studied the role ...
Efeito dos ligantes do Receptor do Fator de Crescimento Epidermal (EGFR) para sua translocação nuclear
(Universidade Federal de Minas GeraisUFMG, 2015-02-25)
The epidermal growth factor receptor (EGFR) once in touch with their ligands is activated and becomes able to generate a range of signals such as proliferation, differentiation, migration and cell survival. Recent studies ...