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Helminths turning on the NLRP3 inflammasome: Pros and cons
(Elsevier, 2020-02)
Helminth infections can activate multimeric protein complexes called inflammasomes. In this forum we summarize the main effects of the NLRP3 inflammasome activation, including control of excessive Th2 response and ...
NLRP1 L155H polymorphism is a risk factor for preeclampsia development
(Wiley-Blackwell, 2015-06-01)
Problem: Augmented levels of IL-1 ss have been pointed out as an important pathogenic factor for preeclampsia development. Inflammasome is the cytoplasmic complex responsible for pro-IL1 ss cleavage and IL-1 ss secretion. ...
Calcium sensing receptor activation in THP-1 macrophages triggers NLRP3 inflammasome and human preadipose cell inflammation
(Elsevier, 2020)
Excess adipose tissue (AT) associates with inflammation and obesity-related diseases. We studied whether calcium-sensing receptor (CaSR)-mediated NLRP3 inflammasome activation in THP-1 macrophages elevates inflammation in ...
Increased expression of NLRP3 inflammasome in placentas from pregnant women with severe preeclampsia
(Elsevier B.V., 2017-09-01)
Preeclampsia is a pregnancy disorder characterized by imbalance between pro- and anti-inflammatory cytokines associated with high plasma levels of uric acid and Interleukin-1 beta (IL-1 beta). The inflammasome is a protein ...
Papel do inflamassoma NLRP3 em modelo de infecção sistêmica por Sporothrix schenckii
(Universidade Estadual Paulista (Unesp), 2016-12-09)
A esporotricose é uma infecção fúngica causada pelas espécies do complexo Sporothrix, incluindo Sporothrix schenckii sensu stricto. Os receptores de reconhecimento padrão (PRRs), pertencentes às células da resposta imune ...
Endogenous and uric acid-induced activation of NLRP3 inflammasome in pregnant women with preeclampsia
(Public Library Science, 2015-06-08)
Preeclampsia (PE) is a specific syndrome of pregnancy, characterized by hypertension and proteinuria. This pathology is associated with hyperuricemia and elevated serum levels of inflammatory cytokines. Uric acid crystals ...
Polymorphisms in Inflammasome' Genes and Susceptibility to HIV-1 Infection
(LIPPINCOTT WILLIAMS & WILKINSPHILADELPHIA, 2012)
The involvement of inflammasome genes in the susceptibility to HIV-1 infection was investigated. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 ...
NLRP1 L155H polymorphism is a risk factor for preeclampsia development
(Wiley-Blackwell, 2015)
Silica nanoparticles induce NLRP3 inflammasome activation in human primary immune cells
(Sage PublicationsInmunovirologíaReino Unido, 2019)
Expression of NLRP3 inflammasome in leprosy indicates immune evasion of Mycobacterium leprae
(Fundação Oswaldo Cruz, 2020)