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Aumento en la expresión de DSCAM y su acción sobre parámetros morfológicos neuronales a través de efectores de la vía PAK en un modelo celular del Síndrome de Down
(Universidad de Chile, 2016)
El Síndrome de Down se define como un desorden del desarrollo
causado por la presencia de una copia extra del cromosoma 21, que va
acompañado de anomalías multisistémicas principalmente a nivel del sistema
nervioso ...
Leukotrienes Target F-actin/Cofilin-1 to Enhance Alveolar Macrophage Anti-fungal Activity
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2011)
Candida albicans is the most common opportunistic fungal pathogen and causes local and systemic disease in immunocompromised patients. Alveolar macrophages (AMs) are pivotal for the clearance of C. albicans from the lung. ...
Dinámica del citoesqueleto de actina de la célula hospedadora durante la infección con Coxiella burnetii
(2018-03-20)
Coxiella burnetii (Cb) es un patógeno intracelular obligado que emplea el citoesqueleto de actina, para su internalización y desarrollo dentro de la célula. En este trabajo se estudia el rol de proteínas asociadas a actina ...
A RhoA Signaling Pathway Regulates Dendritic Golgi Outpost Formation
(2015)
The neuronal Golgi apparatus (GA) localizes to the perinuclear region and dendrites as tubulo-vesicular structures designated Golgi outposts (GOPs). Current evidence suggests that GOPs shape dendrite morphology and serve ...
MAP1B Regulates Axonal Development by Modulating Rho-GTPase Rac1 Activity
(AMER SOC CELL BIOLOGY, 2010-08-09)
Cultured neurons obtained from MAP1B-deficient mice have a delay in axon outgrowth and a reduced rate of axonal
elongation compared with neurons from wild-type mice. Here we show that MAP1B deficiency results in a ...
Detection of a Williams Beuren syndrome case by MLPA.
(Medicina (Buenos Aires), 2013-02)
El síndrome de Williams-Beuren (WBS) es un trastorno del desarrollo neurológico que incluye diferentes manifestaciones clínicas como estenosis aórtica supravalvular, lesiones cerebrovasculares, retraso en el crecimiento, ...
El Síndrome de Williams-Reporte de tres casos
(Instituto de Investigaciones en Ciencias de la Salud - UNA, 2007)
A RhoA signaling pathway regulates dendritic Golgi outpost formation
(Cell Press, 2015-04)
Summary The neuronal Golgi apparatus (GA) localizes to the perinuclear region and dendrites as tubulo-vesicular structures designated Golgi outposts (GOPs). Current evidence suggests that GOPs shape dendrite morphology and ...
Alterations in gene expression profiles correlated with cisplatin cytotoxicity in the glioma U343 cell line
(Sociedade Brasileira de Genética, 2010)
Gliomas are the most common tumors in the central nervous system, the average survival time of patients with glioblastoma multiforme being about 1 year from diagnosis, in spite of harsh therapy. Aiming to study the ...
Agonist Effects of Propranolol on Non-Tumor Human Breast Cells
(MDPI, 2020-04-22)
The β-blocker propranolol (PROP) has been proposed as a repurposed treatment for breast cancer. The similarity of action between β-agonists and antagonists found on breast cells encouraged us to compare PROP and isoproterenol ...