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Protective effects of eicosapentaenoic acid plus hydroxytyrosol supplementation against white adipose tissue abnormalities in mice fed a high-fat diet
(MDPI, 2020)
Objective: Obesity induced by high-fat diet (HFD) elicits white adipose tissue dysfunction. In this study, we have hypothesized that the metabolic modulator eicosapentaenoic acid (EPA) combined with the antioxidant ...
Suppression of high-fat diet-induced obesity-associated liver mitochondrial dysfunction by docosahexaenoic acid and hydroxytyrosol co-administration
(Elsevier, 2020)
Objective: Obesity-induced by high-fat diet (HFD) is associated with liver steatosis, oxidative stress and mitochondrial dysfunction, which can be eluded by the co-administration of the lipid metabolism modulator docosahexaenoic ...
Regulation of immune and nonimmune mast cell activation by phenols from olive oil
(IntechOpen, 2019)
The purpose of this study is to establish if hydroxytyrosol and oleuropein, themost significant phenols found in olive oil and olives, can inhibit the activation of mast cells induced by immune and nonimmune pathways. ...
Impact of the co-administration of N-3 fatty acids and olive oil components in preclinical nonalcoholic fatty liver disease models: a mechanistic view
(MDPI, 2020)
Nonalcoholic fatty liver disease (NAFLD) is present in approximately 25% of the population worldwide. It is characterized by the accumulation of triacylglycerol in the liver, which can progress to steatohepatitis with ...
Maternal supplementation with polyphenols and omega-3 fatty acids during pregnancy: prenatal effects on fetal fatty acid composition in the iberian pig
(2022)
Intrauterine Growth Restriction (IUGR) is a major problem in pig production and different strategies, mainly maternal supplementation with different agents, are currently being studied. The combination of hydroxytyrosol ...
Polyphenols and iugr pregnancies: effects of maternal hydroxytyrosol supplementation on placental gene expression and fetal antioxidant status, dna-methylation and phenotype
(2019)
The use of polyphenols is a promising strategy for preventing or alleviating intrauterine growth restriction (IUGR) because polyphenol supplementation increases plasma antioxidant capacity and improves oxidative stress at ...
Polyphenols and IUGR pregnancies: effects of maternal hydroxytyrosol supplementation on postnatal growth, metabolism and body composition of the offspring
(2019)
Maternal supplementation with the polyphenol hydroxytyrosol in a swine model of intrauterine growth restriction (IUGR) improves the fetal oxidative status, decreases the appearance of low birth-weight neonates and favors ...