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Regulation of steroid hormone receptor function by the 52-kDa FK506-binding protein (FKBP52)
(Elsevier, 2011-08)
The large FK506-binding protein FKBP52 has been characterized as an important positive regulator of androgen, glucocorticoid and progesterone receptor signaling pathways. FKBP52 associates with receptor-Hsp90 complexes and ...
The activity of the glucocorticoid receptor is regulated by SUMO conjugation to FKBP51
(Nature Publishing Group, 2016-10)
FK506-binding protein 51 (FKBP51) regulates the activity of the glucocorticoid receptor (GR), and is therefore a key mediator of the biological actions of glucocorticoids. However, the understanding of the molecular ...
Dynamic mitochondrial–nuclear redistribution of the immunophilin FKBP51 is regulated by the PKA signaling pathway to control gene expression during adipocyte differentiation
(Company of Biologists, 2013-12)
Glucocorticoids play an important role in adipogenesis via the glucocorticoid receptor (GR) that forms a heterocomplex with Hsp90•Hsp70 and one high molecular weight immunophilin FKBP51 or FKBP52. When 3T3-L1 preadipocytes ...
Biological relevance of Hsp90-binding immunophilins in cancer development and treatment
(John Wiley & Sons Inc, 2016-02)
Immunophilins are a family of intracellular receptors for immunosuppressive drugs. Those immunophilins that are related to immunosuppression are the smallest proteins of the family, i.e., FKBP12 and CyPA, whereas the other ...
Peptidyl‐Prolyl Isomerase Activity of Immunophilins Could Be the Mere Consequence of Protein Complex Organization
(John Wiley & Sons Inc, 2020-05)
Immunophilins comprise a family of proteins characterized by the presence of a specific sequence that usually shows peptidyl‐prolyl‐(cis/trans )‐isomerase (PPIase) activity, i.e., the reversible cis/trans interconversion ...
Hsp90-binding immunophilins as a potential new platform for drug treatment
(Future Science, 2013-04)
Immunophilins are proteins that contain a PPIase domain as a family signature. Low-molecular-weight immunophilins were first described associated to immunosuppressive action and protein folding. Recent studies of other ...
La redistribución dinámica mitocondria-núcleo de la inmunofilina fkbp51 es regulada por pka para modular la expresión de genes durante el proceso de adipogénesisThe dynamic mitochondria-nuclear redistribution of FKBP51 during the process of adipocyte differentiation is regulated by PKA
(Medicina (Buenos Aires), 2013-11)
Los glucocorticoides tienen un papel central en la adipogénesis, por su unión al receptor RG cito-plasmático formando parte de un heterocomplejo también integrado por una inmunofilina (INM) de alto peso molecular, FKBP51 ...
Galectin-1 Markedly Reduces the Incidence of Resorptions in Mice Missing Immunophilin FKBP52
(Oxford University Press, 2012-05)
Progesterone (P4) signaling is critical for pregnancy.We previously showed that immunopilin FK506 binding protein (FKBP)52 serves as a cochaperone to optimize progesterone receptor (PR) function in the uterus, and its ...
Subcellular rearrangement of Hsp90-binding immunophilins accompanies neuronal differentiation and neurite outgrowth
(Wiley, 2010-11)
FKBP51 and FKBP52 (FK506-binding protein 51 and 52) are tetratricopeptide repeat-domain immunophilins belonging to the tetratricopeptide-protein•hsp90•hsp70•p23 heterocomplex bound to steroid receptors. Immunophilins are ...
The emerging role of TPR-domain immunophilins in the mechanism of action of action of steroid receptors
(AgiAL Publishing Group, 2014-11-30)
In the absence of ligand, some members of nuclear receptor family such as corticosteroid receptors are primarily located in the cytoplasm, and they rapidly accumulate in the nucleus upon ligand-binding. Other members of ...