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Signaling pathways of cell proliferation are involved in the differential effect of erythropoietin and its carbamylated derivative
(Elsevier Science, 2013-08)
It is now recognized that in addition to its activity upon erythroid progenitor cells, erythropoietin (Epo) is capable of stimulating survival of different non-erythroid cells. Since stimulation of erythropoiesis is unwanted ...
Endogenous erythropoietin signaling facilitates skeletal muscle repair and recovery following pharmacologically induced damage
(Wiley, 2012)
Erythropoietin acts by binding to its cell surface receptor on erythroid progenitor cells to stimulate erythrocyte production. Erythropoietin receptor expression in nonhematopoietic tissue, including skeletal muscle ...
Modification of erythropoietin structure by N-homocysteinylation affects its antiapoptotic and proliferative functions
(Wiley Blackwell Publishing, Inc, 2018-10)
Many patients under therapy with recombinant human erythropoietin (rhuEPO) show resistance to the treatment, an effect likely associated with the accumulation of tissue factors, especially in renal and cardiovascular ...
Erythropoietin and the polycythemia of high-altitude wellers
(Molecular Biology of Erythropoiesis, 1989)
Abstract
High-altitude natives residing at similar altitudes exhibit varying degrees of erythrocytosis, depending in part upon their geographical location. A recent report by Winslow et al suggests that hematocrit and ...
High-Altitude Hypoxia Decreases Plasma Erythropoietin Soluble Receptor Concentration in Lowlanders
(Mary Ann Liebert, 2020)
Background: The soluble form of the erythropoietin (Epo) receptor (sEpoR) is an endogenous antagonist of Epo. Decreasing plasma sEpoR increases free Epo, thereby increasing the availability of the hormone. In humans, ...
Erythropoietin and the use of a transgenic model of erythropoietin-deficient mice
(Dove Medical Press, 2016)
Despite its well-known role in red blood cell production, it is now accepted that erythropoietin (Epo) has other physiological functions. Epo and its receptors are expressed in many tissues, such as the brain and heart. ...
Hypoxia and erythropoietin in the regulation of aquaporins
(Nova Science Publishers, 2020)
Aquaporins (AQPs) constitute a family of small transmembrane proteins that facilitate osmotically-driven water transport, and in some cases that of small solutes. Several roles for AQPs have been identified, such as the ...
Neuroprotective activity of a new erythropoietin formulation with increased penetration in the central nervous system
(Biomed central, 2011-11)
Apart from its hematopoietic effect, erythropoietin (EPO) is a molecule with high neuroprotective potential. However, its prolonged application may cause serious adverse effects due to the erythropoiesis stimulation. ...