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Cannabidiol inhibits the hyperphagia induced by cannabinoid-1 or serotonin-1A receptor agonists
(PERGAMON-ELSEVIER SCIENCE LTD, 2011)
Delta 9-THC is a component of Cannabis sativa that increases food intake in animals and humans, an effect prevented by selective CB1 receptor antagonists. Cannabidiol (CBD) is another constituent of this plant that promotes ...
Efectos de la exposición prenatal al agonista cannabinoide WIN55,212-2 sobre la proliferación, la migración y el citoesqueleto neuronal de la rataEffect of prenatal exposure to the cannabinoide receptor agonist WIN55,212-2 on neuronal proliferation, migration and neuronal cytoskeleton in the cerebral cortex of the rat
(Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires, 2012)
Expression analysis of cannabinoid receptors 1 and 2 in B cells during pregnancy and their role on cytokine production
(Elsevier Ireland, 2016-08)
The endocannabinoid system consists in a family of lipids that binds to and activates cannabinoid receptors. There are two receptors so far described, the cannabinoid receptor 1 (CB1) and 2 (CB2). In the context of pregnancy, ...
Islet Cannabinoid Receptors Cellular Distribution and Biological Function
(Lippincott, Williams, 2013-10)
Objectives: To determine the cellular distribution of islet cannabinoid receptors (CBs) and their involvement in the development of metabolic and hormonal changes in rats fed a fructose-rich diet (F). Methods: In normal ...
Design, Synthesis, Binding and Docking-Based 3D-QSAR Studies of 2-Pyridylbenzimidazoles—A New Family of High Affinity CB1 Cannabinoid Ligands
(2013)
A series of novel 2-pyridylbenzimidazole derivatives was rationally designed and synthesized based on our previous studies on benzimidazole 14, a CB1 agonist used as a template for optimization. In the present series, 21 ...
Blockade of Cannabinoid CB1 Receptors in the Dorsal Periaqueductal Gray Unmasks the Antinociceptive Effect of Local Injections of Anandamide in Mice
(Frontiers Media Sa, 2017-10-04)
Divergent results in pain management account for the growing number of studies aiming at elucidating the pharmacology of the endocannabinoid/endovanilloid anandamide (AEA) within several pain-related brain structures. For ...
Opposing Roles for Cannabinoid Receptor Type-1 (CB1) and Transient Receptor Potential Vanilloid Type-1 Channel (TRPV1) on the Modulation of Panic-Like Responses in Rats
(NATURE PUBLISHING GROUPLONDON, 2013-08-02)
The midbrain dorsal periaqueductal gray (dPAG) has an important role in orchestrating anxiety-and panic-related responses. Given the cellular and behavioral evidence suggesting opposite functions for cannabinoid type 1 ...
Mastering tricyclic ring systems for desirable functional cannabinoid activity
(Elsevier Masson, 2013-11)
There is growing interest in using cannabinoid receptor 2 (CB2) agonists for the treatment of neuropathic pain and other indications. In continuation of our ongoing program aiming for the development of new small molecule ...