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Mostrando ítems 11-20 de 91
Physiology, molecular biology and therapeutic potential of the thymic peptide thymulin
(Sociedad Argentina de Fisiología, 2012-10)
Thymulin is a thymic hormone exclusively produced by the thymic epithelial cells. After its discovery and initial characterization in the ‘70s, it was demonstrated that thymulin production and secretion is strongly influenced ...
Crotalphine induces potent antinociception in neuropathic pain by acting at peripheral opioid receptors
(ELSEVIER SCIENCE BV, 2008)
Neuropathic pain is an important clinical problem and it is usually resistant to the current therapy. We have recently characterized a novel analgesic peptide, crotalphine, from the venom of the South American rattlesnake ...
Síntese e estudo da atividade antinociceptiva de Pep13, peptídeo derivado de PnTx4(6-1), uma toxina da peçonha da aranha Phoneutria nigriventer
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAPrograma de Pós-Graduação em Bioquímica e ImunologiaUFMG, 2017-05-15)
The venom of the “armed” spider Phoneutria nigriventer has several biologically active peptides, one of them the toxin PnTx4(6-1) is a peptide composed of 48 amino acid residues and molecular mass of 5.2 kDa. PnTx4(6-1), ...
No Change in Interictal PACAP Levels in Peripheral Blood in Women With Chronic Migraine
(Blackwell Publishing Inc., 2016)
Estudo da atividade antinociceptiva do peptídeo sintético PnPP-19
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAPrograma de Pós-Graduação em Bioquímica e ImunologiaUFMG, 2018-02-23)
The toxin PnTx2-6, isolated from the venom of the spider Phoneutria nigriventer, is very toxic (LD50 = 0.7 μg/mouse) and has been studied as a molecule that improves erectile function. Besides this effect, this toxin induces ...
Efeitos clínico, comportamental e antinociceptivo da crotalfina em equinos
(2016-04-01)
Crotalphine is a novel analgesic peptide that acts on kappa opioid and delta receptors, causing powerful analgesia in rats submitted to inflammatory, neuropathic or oncologic models of pain. This study evaluated clinical, ...
Participação do sistema endocanabinoidérgico no mecanismo antinociceptivo da ketamina
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em Ciências Biológicas - Fisiologia e FarmacologiaUFMG, 2014-04-03)
The ability to feel pain is essential for maintenance of the life, without her
tissue trauma would not be detected or prevented, causing significant tissue
and nerve damage. The discovery of new analgesic mechanisms ...