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Amyloid β peptide decreases α7 receptor potentiation
(Fundación Revista Medicina, 2017)
Amyloid β peptide (Aβ) is a key player in the development of Alzheimer disease (AD). Aβ is visible as the primary component of senile plaques in the brains of Alzheimer’s patients. Cholinergic activity mediated by human ...
Binding Modes of Phthalocyanines to Amyloid β Peptide and Their Effects on Amyloid Fibril Formation
(Cell Press, 2018-03)
The inherent tendency of proteins to convert from their native states into amyloid aggregates is associated with a range of human disorders, including Alzheimer's and Parkinson's diseases. In that sense, the use of small ...
Transcriptional regulation of insulin-degrading enzyme modulates mitochondrial amyloid β (Aβ) peptide catabolism and functionality
(American Society For Biochemistry And Molecular Biology, 2013-05)
Studies of post-mortem brains from Alzheimer disease patients suggest that oxidative damage induced by mitochondrial amyloid β (mitAβ) accumulation is associated with mitochondrial dysfunction. However, the regulation of ...
Vitamin E but not 17β-estradiol protects against vascular toxicity induced by β-amyloid wild type and the dutch amyloid variant
(2002)
Amyloid β-peptide (Aβ) fibril deposition on cerebral vessels produces cerebral amyloid angiopathy that appears in the majority of Alzheimer's disease patients. An early onset of a cerebral amyloid angiopathy variant called ...
Activation of Wnt Signaling Protects from Amyloid-β-peptide Neurotoxicity
(Hanin, I.Cacabelos, R.Fisher, A.Taylor & Francis London, New York, 2005)
Wnt signaling is essential in cell adhesion and regulation of cell fate determination during development.1,2 Recently, it has been implicated in oncogenic processes and in neurodegenerative disorders such as autism, ...
Acetylcholinesterase in Alzheimer’s Disease: Its Molecular Interactions with the Amyloid β peptide
(Parveen, M.Kumar, S.IOS Press, Amsterdam, Berlin, Oxford, Tokio, Washington DC, 2005)
A QM/MM study of the molecular recognition site of bapineuzumab toward the amyloid-β peptide isoforms
(Taylor & Francis Ltd, 2016-02)
The molecular mechanism of recognition of amyloid-beta (Aβ) peptide isoforms by bapineuzumab was studied using a quantum mechanics and molecular mechanics (QM/MM) method. In this work, geometric optimisations were performed ...