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Calcineurin/P38MAPK/HSP27-dependent pathways are involved in the attenuation of postischemic mitochondrial injury afforded by sodium bicarbonate co-transporter (NBCe1) inhibition
(Elsevier Science Inc., 2019-03)
The electrogenic sodium bicarbonate co-transporter isoform 1 (NBCe1) plays an important role in ischemia-reperfusion injury. The cardioprotective action of an antibody directed to the extracellular loop 3 (a-L3) of NBCe1 ...
Cardioproteção induzida por p-cimeno contra danos contráteis e oxidativos decorrentes das lesões de reperfusão em ratosp-Cymene induced cardioprotection against contractile and oxidative damage from reperfusion injury in rats
(Pós-Graduação em Ciências da SaúdeUniversidade Federal de Sergipe, 2018)
Chemical chaperones improve the functional recovery of stunned myocardium by attenuating the endoplasmic reticulum stress
(Wiley Blackwell Publishing, Inc, 2019-08-05)
Aim: Myocardial ischaemia/reperfusion (I/R) produces structural and functional alterations depending on the duration of ischaemia. Brief ischaemia followed by reperfusion causes reversible contractile dysfunction (stunned ...
Protection of the myocardium against ischemia/reperfusion injury by angiotensin-(1–9) through an AT2R and Akt-dependent mechanism
(Academic Press, 2018)
© 2018 Elsevier Ltd Angiotensin-(19), a peptide of the non-classical renin angiotensin system, has been shown to prevent and revert hypertension and cardiac hypertrophy. We hypothetized that systemic delivery of angiotensin-(1–9) ...
Antiarrhythmic effect linked to melatonin cardiorenal protection involves AT1 reduction and Hsp70-VDR increase
(Wiley Blackwell Publishing, Inc, 2018-11)
Lethal ventricular arrhythmias increase in patients with chronic kidney disease that suffer an acute coronary event. Chronic kidney disease induces myocardial remodeling, oxidative stress, and arrhythmogenesis. A manifestation ...
Ex Vivo Treatment with a Polyphenol-Enriched Cocoa Extract Ameliorates Myocardial Infarct and Postischemic Mitochondrial Injury in Normotensive and Hypertensive Rats
(American Chemical Society, 2016-06)
Our objective was to determine the effects of a polyphenol-enriched cocoa extract (PCE) on myocardial postischemic alterations in normotensive (Wistar rats, W) and spontaneously hypertensive rats (SHR). Isolated hearts ...