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Oxidation of acetylacetone catalyzed by horseradish peroxidase in the absence of hydrogen peroxide
(Elsevier B.V., 2006-12-01)
Horseradish peroxidase (HRP) is a plant enzyme widely used in biotechnology, including antibody-directed enzyme prodrug therapy (ADEPT). Here, we showed that HRP is able to catalyze the autoxidation of acetylacetone in the ...
Drug/Lead Compound Hydroxymethylation as a Simple Approach to Enhance Pharmacodynamic and Pharmacokinetic Properties
(2022-02-14)
Hydroxymethylation is a simple chemical reaction, in which the introduction of the hydroxymethyl group can lead to physical–chemical property changes and offer several therapeutic advantages, contributing to the improved ...
Anti-inflammatory drug design by molecular hybridization approach
(2011)
The design of new drugs with better physiochemical properties, adequateabsorption, distribution, metabolism, and excretion, effective pharmacologic potency andlacking toxicity remains is a challenge. Inflammation is the ...
The triad indole-3-acetic acid ethyl ester/esterase/horseradish peroxidase as a new cytotoxic prodrug/enzyme combination
(2010)
The antibody-directed enzyme prodrug therapy (ADEPT) is a means of restricting the action of toxic drugs to the tumor site. The enzyme/prodrug pair horseradish peroxidase (HRP)/indole-3-acetic acid (IAA) has been studied ...
Pharmacokinetics of hydroxymethylnitrofurazone and its parent drug nitrofurazone in rabbits
(2013-01-01)
The prodrug hydroximethylnitrofurazone (NFOH) presents antichagasic activity with greatly reduced toxicity compared to its drug matrix nitrofurazone (NF). Besides these new characteristics, the prodrug was more active ...
Pharmacokinetics of hydroxymethylnitrofurazone and its parent drug nitrofurazone in rabbits
(Drug Metabolism Letters, 2013)
The prodrug hydroximethylnitrofurazone (NFOH) presents antichagasic activity with greatly reduced toxicity compared to its drug matrix nitrofurazone (NF). Besides these new characteristics, the prodrug was more active ...
Synthesis and evaluation of a pyrazinoic acid prodrug in Mycobacterium tuberculosis
(Elsevier B.V., 2015)