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The physiological role of the unfolded protein response in plants
(Sociedad de Biología de Chile, 2011)
Mechanisms, regulation and functions of the unfolded protein response
(Nature, 2020)
The unfolded protein response (UPR) comprises a network of signalling pathways that reprogramme transcription, translation and protein modifications to relieve the load of unfolded or misfolded proteins in the endoplasmic ...
Role of the unfolded protein response in organ physiology: lessons from mouse models
(2013)
The endoplasmic reticulum (ER) is a key subcellular compartment involved in the folding and maturation of around one-third of the total proteome. Accumulation of misfolded proteins in the ER lumen engages a signal transduction ...
Targeting the unfolded protein response for disease intervention
(Taylor & Francis, 2015)
Introduction: The accumulation of misfolded proteins in the endoplasmic reticulum (ER)
generates a stress condition that engages the unfolded protein response (UPR). The UPR is an
adaptive reaction that aims to reestablish ...
Knots can impair protein degradation by ATP-dependent proteases
(National Academy of Sciences, 2017)
ATP-dependent proteases translocate proteins through a narrow pore for their controlled destruction. However, how a protein substrate containing a knotted topology affects this process remains unknown. Here, we characterized ...
Targeting of the unfolded protein response (UPR) as therapy for Parkinson's disease
(Wiley-Blackwell Publishing Ltd, 2019)
Parkinson's disease is the second most common neurodegenerative disorder, leading to the progressive decline of motor control due to the loss of dopaminergic neurons in the substantia nigra pars compacta. At the molecular ...
The stress rheostat: an interplay between the unfolded protein response (UPR) and autophagy in neurodegeneration
(2008)
The unfolded protein response (UPR) is a conserved adaptive reaction that increases cell survival under conditions of endoplasmic reticulum (ER) stress. The UPR controls diverse processes such as protein folding, secretion, ...
Commentary: XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity
(Frontiers Media, 2016)