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Autoradiogsaphic study of (6.7-3H)oestradiol-17β incorporation into rat uterus
(1967)
(6,7-3H) oestradiol-17β incorporation by the rat uterus has been studied using autoradiography. The cytoplasm and/or the cellular membrane of uterine eosinophilic cells seems to incorporate oestradiol in a much greater ...
Cross-talk with β2-adrenoceptors enhances ligand affinity properties from endothelial alpha1D-adrenoceptors that mediates carotid relaxation
(2013-09-01)
Objectives Our main objectives were to investigate the affinity properties of endothelial and muscular α1D-adrenoceptors and to characterize the cross-talk between endothelial α1D- adrenoceptors and β2-adrenoceptors in rat ...
Cross-talk with β2-adrenoceptors enhances ligand affinity properties from endothelial alpha1D-adrenoceptors that mediates carotid relaxation
(2013-09-01)
Objectives Our main objectives were to investigate the affinity properties of endothelial and muscular α1D-adrenoceptors and to characterize the cross-talk between endothelial α1D- adrenoceptors and β2-adrenoceptors in rat ...
Complexity-entropy maps as a tool for the characterization of the clinical electrophysiological evolution of patients under pharmacological treatment with psychotropic drugs
(Molecular Diversity Preservation International, 2017-10-13)
In the clinical electrophysiological practice, reading and comparing electroencephalographic (EEG) recordings are sometimes insufficient and take too much time. Tools coming from the information theory or nonlinear systems ...
Entinostat (SNDX-275) for the treatment of non-small cell lung cancer
(Taylor and Francis, 2015)
INTRODUCTION: Epigenetic aberrations play an important role in lung carcinogenesis. Chromatin deacetylation is a fundamental mechanism of gene silencing. Histone deacetylase (HDAC) inhibitors are an emerging class of ...
High Density Lipoproteins: From Biological Understanding to Clinical Exploitation
In both epidemiological and clinical studies as well as the meta-analyses thereof,
low plasma levels of high-density lipoprotein (HDL) cholesterol (HDL-C)
identified individuals at increased risk of major coronary events. ...
Cardiac Remodeling: Concepts, Clinical Impact, Pathophysiological Mechanisms and Pharmacologic Treatment
(2016-01-01)
Cardiac remodeling is defined as a group of molecular, cellular and interstitial changes that manifest clinically as changes in size, mass, geometry and function of the heart after injury. The process results in poor ...
Repurposing available drugs for neurodevelopmental disorders: The fragile X experience
(Elsevier Ltd, 2019)
Many available drugs have been repurposed as treatments for neurodevelopmental disorders. In the specific case of fragile X syndrome, many clinical trials of available drugs have been conducted with the goal of disease ...