Buscar
Mostrando ítems 1-10 de 1516
High frequency of p 16 promoter methylation in non-small cell lung carcinomas from Chile
(2007)
The inactivation of tumour suppressor genes by aberrant methylation of promoter regions has been described as a frequent event in neoplasia development, including lung cancer. The p16 gene is a tumour suppressor gene ...
Correlation of MGMT promoter methylation status with gene and protein expression levels in glioblastoma
(Faculdade de Medicina / USP, 2011)
OBJECTIVES: 1) To correlate the methylation status of the O6-methylguanine-DNA-methyltransferase (MGMT) promoter to its gene and protein expression levels in glioblastoma and 2) to determine the most reliable method for ...
High frequency of p 16 promoter methylation in non-small cell lung carcinomas from Chile
(Sociedad de Biología de Chile, 2007)
CDKN2A promoter hypermethylation in astrocytomas is associated with age and sex
(2013-06-12)
CDKN2A promoter hypermethylation has been widely related to many cancers. In astrocytomas, although CDKN2A (p16INK4A protein) is often inactivated, there are still some controversial issues regarding the mechanism by which ...
MGMT promoter methylation in Peruvian patients with glioblastoma
(ecancerPE, 2018)
Purpose: O6 -methylguanine–DNA methyltransferase (MGMT) promoter methylation predicts the outcome and response to alkylating
chemotherapy in glioblastoma. The aim of this study is to evaluate the prevalence of MGMT ...
Methylation of TFAM gene promoter in peripheral white blood cells is associated with insulin resistance in adolescents
(Academic Press Inc Elsevier Science, 2010-05)
Purpose: To explore whether DNA methylation of the mitochondrial transcription factor A (TFAM) promoter is associated with insulin resistance in a sample of adolescents with features of metabolic syndrome. Methods: The ...
MGMT and MLH1 methylation in Helicobacter pylori-infected children and adults
(2013-05-31)
AIM: To evaluate the association between Helicobacter pylori(H. pylori) infection and MLH1 and MGMT methylation and its relationship with microsatellite instability (MSI). METHODS: The methylation status of the MLH1 and ...
MGMT and MLH1 methylation in Helicobacter pylori-infected children and adults
(2013-05-31)
AIM: To evaluate the association between Helicobacter pylori(H. pylori) infection and MLH1 and MGMT methylation and its relationship with microsatellite instability (MSI). METHODS: The methylation status of the MLH1 and ...
Analysis of aberrant methylation on promoter sequences of tumor suppressor genes and total DNA in sputum samples: A promising tool for early detection of COPD and lung cancer in smokers
(2012)
Background: Chronic obstructive pulmonary disease (COPD) is a disorder associated to cigarette smoke and lung cancer (LC). Since epigenetic changes in oncogenes and tumor suppressor genes (TSGs) are clearly important in ...
Methylation status of ANAPC1, CDKN2A and TP53 promoter genes in individuals with gastric cancer
(Associação Brasileira de Divulgação Científica, 2008)
Gastric cancer is the forth most frequent malignancy and the second most common cause of cancer death worldwide. DNA methylation is the most studied epigenetic alteration, occurring through a methyl radical addition to the ...