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Renal expression and urinary excretion of Na+/dicarboxylate cotransporter 1 (NaDC1) in obstructive nephropathy: a candidate biomarker for this pathology
(Springer, 2018-12)
Obstructive nephropathy is characterized by alterations in renal function that depends on the degree and type of obstruction. To increase the knowledge about the physiopathological mechanisms involved in the renal damage ...
Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy
(Springer, 2015-07-31)
Urinary heat shock protein 70 (Hsp70) is rapidly increased in patients with clinical acute kidney injury, indicating that it constitutes a component of the endogenous stress response to renal injury. Moreover, experimental ...
Renal Expression and Urinary Excretion of Na-K-2Cl Cotransporter in Obstructive Nephropathy
(Hindawi Publishing Corporation, 2017-01)
Renal damage due to urinary tract obstruction accounts for up to 30% of acute kidney injury in paediatrics and adults. Bilateral ureteral obstruction (BUO) is associated with polyuria and reduced urinary concentrating ...
Hepatic and renal expression of Oatp1 in obstructive uropathy. First detection of Oatp1 in urine, a potential biomarker
(Wiley Blackwell Publishing, Inc, 2021-07)
Obstructive renal diseases affect renal function and kidney integrity. Nevertheless, little is known about its systemic or extra-renal effects. The organic anion transporting polypeptide 1 (Oatp1) is a carrier expressed ...
WT-1 Expresion linked to nitric oxide availability during neonatal obstructive nephropathy
(Hindawi Publishing Corporation, 2013-11)
The wt-1 gene encodes a zinc finger DNA-binding protein that acts as a transcriptional activator or repressor depending on the cellular or chromosomal context. The wt-1 regulates the expression of a large number of genes ...
Moduladores de fibrosis y apoptosis asociados a la disponibilidad de on: Efecto de rosuvastanina en nefropatia obstructiva neonatal
(Grupo Bio SRL, 2010-06)
Wilms tumor gene 1 (wt-1), a key regulator of mesenchymal-epithelial transformation, is downregulated during congenital obstructive nephropathy, leading to apoptosis. There is a functional interaction between WT-1 and ...
Heat shock protein 70/nitric oxide effect on stretched tubular epithelial cells linked to WT-1 cytoprotection during neonatal obstructive nephropathy
(Springer, 2017-10)
Background Mechanical stress is a key pathogenic driver of apoptosis in the tubular epithelium in obstructive nephropathy. Heat shock protein 70 (Hsp70) and Wilms’ tumor (WT-1) have been proposed to represent linked ...
Cytoprotective role of nitric oxide associated with Hsp70 expression in neonatal obstructive nephropathy
(Academic Press Inc Elsevier Science, 2008-12)
Nitric oxide (NO) has emerged as an important endogenous inhibitor of apoptosis. In this study, we postulated that the mechanism of apoptosis inhibition by NO would include stimulation of heat shock protein 70 (Hsp70) ...
Role of mitochondria in paricalcitol-mediated cytoprotection during obstructive nephropathy
(American Physiological Society, 2012-04-04)
Vitamin D slows the progression of chronic kidney disease. Furthermore, activators of vitamin D receptors (VDR) have suppressant effects on the renin-angiotensin system, as well as anti-inflammatory and antifibrotic actions. ...