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Nrf2-peroxiredoxin I axis in polymorphous adenocarcinoma is associated with low matrix metalloproteinase 2 level
(Springer, 2017-12-01)
Polymorphous adenocarcinoma (PAC) is a malignant epithelial neoplasm that affects almost exclusively the minor salivary glands, generally described as having a relatively good prognosis. Aberrant nuclear factor erythroid ...
Dual TNFα-induced effects on NRF2 mediated antioxidant defence in astrocyte-rich cultures: role of protein kinase activation
(Springer, 2012-12)
Tumor necrosis factor-α (TNFα) is a pleiotropic molecule that can have both protective and detrimental effects in neurodegeneration. Here we have investigated the temporal effects of TNFα on the inducible Nrf2 system in ...
SARS-CoV2-mediated suppression of NRF2- signaling reveals potent antiviral and anti- inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV2) and the pathogenic consequences of COVID-19 are urgently required. Here, we
demonstrate that the NRF2 antioxidant gene expression ...
The role of nuclear factor erythroid 2–related factor 2 (NRF2) in normal and pathological pregnancy: A systematic review
(2021-01-01)
Objective: A homeostatic balance between reactive oxygen species production and the antioxidant redox system is an important component of normal pregnancy. Nuclear Factor Erythroid 2–Related Factor 2 (Nrf2) preserves ...
Time-dependent effects of systemic lipopolysaccharide injection on regulators of antioxidant defense Nrf2 and PGC-1alpha in neonatal rat brain.
(Karger, 2013-04)
Background/Aims: Both excitotoxicity and neuroinflammation are associated with oxidative stress. One transcription factor, nuclear factor E2-related factor 2 (Nrf2), and one transcription cofactor, peroxisome proliferato ...
Zinc and the modulation of Nrf2 in human neuroblastoma cells
(Elsevier Science Inc, 2020-08)
Zinc plays a key role in the modulation of neuronal redox homeostasis. A decreased zinc availability is associated with neuronal NADPH oxidase and nitric oxide synthase activation, deregulation of redox signaling, and ...