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Mucosal immune tolerance at the ocular surface in health and disease
(Wiley Blackwell Publishing, Inc, 2017-04)
The ocular surface is constantly exposed to environmental irritants, allergens and pathogens, against which it can mount a prompt immune response to preserve its integrity. But to avoid unnecessary inflammation, the ocular ...
Age-related changes in ocular mucosal tolerance: Lessons learned from gut and respiratory tract immunity
(Wiley Blackwell Publishing, Inc, 2021-04)
The ocular surface is the part of the visual system directly exposed to the environment, and it comprises the cornea, the first refractive tissue layer and its surrounding structures. The ocular surface has evolved to keep ...
A sweet path toward tolerance in the gut
(Nature Publishing Group, 2010-10)
Uncovering how the immune system of the mucosa surmounts allergic reactions may open new avenues to treat inflammatory conditions in the gut. New findings in mice now show that a C-type lectin receptor in dendritic cells ...
Desiccating stress-induced disruption of ocular surface immune tolerance drives dry eye disease
(British Society for Immunology, 2016)
Dry eye is an allegedly autoimmune disorder for which the initiatingmechanisms and the targeted antigens in the ocular surface are not known,yet there is extensive evidence that a localized T helper type 1 (Th1)/Th17effector ...
A phase III randomized double-blind placebo-controlled clinical trial to determine the efficacy of low level laser therapy for the prevention of oral mucositis in patients undergoing hematopoietic cell transplantation
(Springer, 2007-10-01)
Introduction Oral mucositis (OM) is a significant early complication of hematopoietic cell transplantation (HCT). This phase III randomized double-blind placebo-controlled study was designed to compare the ability of 2 ...
A phase III randomized double-blind placebo-controlled clinical trial to determine the efficacy of low level laser therapy for the prevention of oral mucositis in patients undergoing hematopoietic cell transplantation
(Springer, 2007-10-01)
Introduction Oral mucositis (OM) is a significant early complication of hematopoietic cell transplantation (HCT). This phase III randomized double-blind placebo-controlled study was designed to compare the ability of 2 ...
The mucosal surfaces of both eyes are immunologically linked by a neurogenic inflammatory reflex involving TRPV1 and substance P
(Nature Publishing Group, 2018-09)
Immunological interdependence between the two eyes has been reported for the cornea and the retina but not for the ocular mucosal surface. Intriguingly, patients frequently report ocular surface-related symptoms in the ...
Efeitos do envelhecimento na mucosa intestinal: indução e declínio da tolerância oral
(Universidade Federal de Minas GeraisUFMG, 2011-02-18)
Aging is reported to be associated with a decline in oral tolerance induction, an immunological phenomenon initiated at the intestinal mucosal surface. Mice become less susceptible with 24 weeks of age and totally refractory ...
Dietary retinol role and retinoic acid adjuvant effect in mucosal LaAg vaccine efficacy against Leishmania amazonensis infection
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2018)