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Hsp90-binding immunophilin FKBP51 forms complexes with hTERT enhancing telomerase activity
(Elsevier, 2016-05-17)
FK506-binding proteins are members of the immunophilin family of proteins. Those immunophilins associated to the 90-kDa-heat-shock protein, Hsp90, have been proposed as potential modulators of signalling cascade factors ...
Regulation of FKBP51 and FKBP52 functions by post-translational modifications
(Portland Press, 2019-10)
FKBP51 and FKBP52 are two iconic members of the family of peptidyl-prolyl-(cis/trans)-isomerases (EC: 5.2.1.8), which comprises proteins that catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds in unfolded ...
Proof that the high molecular weight immunophilin FKBP52 mediates the in vivo neuroregenerative effect of the macrolide FK506
(Pergamon-Elsevier Science Ltd, 2020-12)
The immunosuppressant drug FK506 (or tacrolimus) is a macrolide that binds selectively to immunophilins belonging to the FK506-binding protein (FKBP) subfamily, which are abundantly expressed proteins in neurons of the ...
Biological actions of the hsp90-binding immunophilins FKBP51 and FKBP52
(Multidisciplinary Digital Publishing Institute, 2019-08)
Immunophilins are a family of proteins whose signature domain is the peptidylprolylisomerase domain. High molecular weight immunophilins are characterized by the additional presence of tetratricopeptide-repeats (TPR) through ...
Immunophilins FKBP51 and FKBP52
(MDPI, 2019)
Immunophilins are a family of proteins whose signature domain is the peptidylprolyl-isomerase domain. High molecular weight immunophilins are characterized by the additional presence of tetratricopeptide-repeats (TPR) ...
NF-κB transcriptional activity is modulated by FK506-binding proteins FKBP51 and FKBP52: a role for peptidyl-prolyl isomerase activity
(American Society for Biochemistry and Molecular Biology, 2014-08)
Hsp90 binding immunophilins FKBP51 and FKBP52 modulate steroid receptor trafficking and hormone-dependent biological responses. With the purpose to expand this model to other nuclear factors that are also subject to ...
Acción biológica de la inmunofilina de alto peso molecular FKBP51 en procesos malignos
(2017-11-27)
Las inmunofilinas son proteínas con actividad enzimática de peptidilprolyl-isomerasa que unen drogas inmunosupresoras. La inmunofilina FKBP51 forma complejos con la chaperona HSP90 y une al macrólido FK506. En este trabajo, ...
The Hsp90-binding immunophilin FKBP52 fosters neurodifferentiation and neuroregeneration in murine models
(Shenyang Editorial Dept Neural Regeneration Res, 2021-02)
The term immunophilin involves a family of proteins whose signature domain shows peptidyl-prolyl-(cis/trans)-isomerase (PPIase) enzymatic activity, i.e., the reversible cis/trans interconversion of Xaa-Pro bonds (Erlejman ...
FKBP51 and FKBP52 in signaling and disease
(Elsevier, 2011-12)
FKBP51 and FKBP52 are diverse regulators of steroid hormone receptor signaling, including receptor maturation, hormone binding and nuclear translocation. Although structurally similar, they are functionally divergent, which ...
The activity of the glucocorticoid receptor is regulated by SUMO conjugation to FKBP51
(Nature Publishing Group, 2016-10)
FK506-binding protein 51 (FKBP51) regulates the activity of the glucocorticoid receptor (GR), and is therefore a key mediator of the biological actions of glucocorticoids. However, the understanding of the molecular ...