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RNA activation: A diamond in the rough for genome engineers
(Wiley-liss, Div John Wiley & Sons Inc, 2017-06)
The ability to develop efficient and versatile technologies for manipulating gene expression is a fundamental issue both in biotechnology and therapeutics. The endogenous RNA interference (RNAi) pathway which mediates gene ...
Dynamic RNA structures in the dengue virus genome
(Landes Bioscience, 2011)
Dengue virus is an important human pathogen that belongs to the Flaviviridae family. The viral genome is a single molecule of RNA of positive polarity that plays multiple roles during the viral life cycle. Besides encoding ...
Identifying trypanosome protein-RNA interactions using RIP-Seq
(Humana Press, 2020)
Trypanosomatids rely primarily on post-transcriptional mechanisms for the control of gene expression, with regulation of RNA processing, localization, degradation and translation by RNA-binding proteins (RBPs). To determine ...
Long-Range RNA-RNA Interactions Circularize the Dengue Virus Genome
(American Society for Microbiology, 2005-05)
Secondary and tertiary RNA structures present in viral RNA genomes play essential regulatory roles during translation, RNA replication, and assembly of new viral particles. In the case of flaviviruses, RNA-RNA interactions ...
Non-canonical roles of tRNAs and tRNA mimics in bacterial cell biology
(Wiley-Blackwell, 2016)
Transfer RNAs (tRNAs) are the macromolecules that transfer activated amino acids from aminoacyl-tRNA synthetases to the ribosome, where they are used for the mRNA guided synthesis of proteins. Transfer RNAs are ancient ...
Pan-cancer chromatin analysis of the human vtRNA genes uncovers their association with cancer biology
(Taylor and Francis, 2021)
Background: The vault RNAs (vtRNAs) are a class of 84-141-nt eukaryotic non-coding RNAs transcribed by RNA polymerase III, associated to the ribonucleoprotein complex known as vault particle. Of the four human vtRNA genes, ...
Epitranscriptomic regulation of HIV-1 full-length RNA packaging
(Oxford University Press, 2022)
During retroviral replication, the full-length RNA serves both as mRNA and genomic RNA. However, the mechanisms by which the HIV-1 Gag protein selects the two RNA molecules that will be packaged into nascent virions remain ...
Competing endogenous RNA networks in the epithelial to mesenchymal transition in diffuse-type of gastric cancer
(MDPI, 2020)
The diffuse-type of gastric cancer is associated with epithelial to mesenchymal transition. Loss of E-cadherin expression is the hallmark of this process and is largely due to the upregulation of the transcription factors ...
vtRNA2-1/nc886 produces a small RNA that contributes to its tumor suppression action through the microRNA pathway in prostate cancer
(MDPI, 2020)
vtRNA2-1 is a vault RNA initially classified as microRNA precursor hsa-mir-886 and recently proposed as “nc886”, a new type of non-coding RNA involved in cancer progression acting as an oncogene and tumor suppressor gene ...