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Morphine withdrawal syndrome: Involvement of the dopaminergic system in prepubertal male and female mice
(Pergamon-Elsevier Science Ltd, 2005-12)
Morphine (MOR) withdrawal signs are more marked in males than in females. Considering that the influence of the dopaminergic system on these differences is unclear, we analyzed dopamine (DA) and dihydroxyphenylacetic-acid ...
Cocaine-induced locomotor activity and cocaine discrimination in dopamine D2 receptor mutant mice
(Springer, 2002-08)
Rationale: Dopamine (DA) D2-like antagonists block several effects of cocaine, including its locomotor stimulant and interoceptive discriminative-stimulus effects. Because these compounds generally lack selectivity among ...
Estudo da participação do sistema dopaminérgico na formação da memória de reconhecimento em ratos
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2006)
It is widely known that the Dopaminergic System plays a relevant role in memory formation and consolidation, however little is known about its role in recognition memory. Thus, the purpose of the present study was to ...
Estudo da participação do sistema dopaminérgico na formação da memória de reconhecimento em ratos
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2006)
It is widely known that the Dopaminergic System plays a relevant role in memory formation and consolidation, however little is known about its role in recognition memory. Thus, the purpose of the present study was to ...
Biochemical and behavioral effects of boldine and glaucine on dopamine systems
(1999)
The aporphine alkaloids boldine and glaucine have been reported to show 'neuroleptic-like' actions in mice, suggesting that they may act as dopamine antagonists. We have found that in vitro boldine displaces specific ...
Synthesis and Dopamine Receptor Selectivity of the Benzyltetrahydroisoquinoline, (R)-(+)-nor-Roefractine
(American Chemical Society and American Society of Pharmacognosy, 1998-01-15)
(R)-(+)-nor-Roefractine (1) was synthesized
by the Bischler-Napieralski route, using asymmetric
reduction of the 1,2-didehydro precursor imine with
sodium (S)-N-CBZ-prolinyloxyborohydride. Compound
1 was able to displace ...
Cocaine-induced locomotor activity and cocaine discrimination in dopamine D4 receptor mutant mice
(Springer, 2003-10)
Rationale: Previous studies have found a role for dopamine D 2-like receptors in many of the behavioral effects of cocaine, including its stimulation of locomotor activity and interoceptive discriminative-stimulus effects. ...
The effects of single-dose injections of modafinil and methamphetamine on epigenetic and functional markers in the mouse medial prefrontal cortex: potential role of dopamine receptors
(Pergamon-Elsevier Science Ltd, 2019-03)
METH use causes neuroadaptations that negatively impact the prefrontal cortex (PFC) leading to addiction and associated cognitive decline in animals and humans. In contrast, modafinil enhances cognition by increasing PFC ...
Effects of some antioxidative aporphine derivatives on striatal dopaminergic transmission and on MPTP-induced striatal dopamine depletion in B6CBA mice
(Elsevier, 2003)
(S)-(+)-boldine, an aporphine alkaloid displaying antioxidative and dopaminergic properties, and six of its derivatives (glaucine, 3-bromoboldine, 3-iodoboldine, 8-aminoboldine, 8-nitrosoboldine and 2,9-O,O′-dipivaloylboldine) ...
Effects on prolactin secretion and binding to dopaminergic receptors in sleep-deprived lupus-prone mice
(Associação Brasileira de Divulgação Científica, 2009-03-01)
Sleep disturbances have far-reaching effects on the neuroendocrine and immune systems and may be linked to disease manifestation. Sleep deprivation can accelerate the onset of lupus in NZB/NZWF1 mice, an animal model of ...