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One-step synthesis of N, N′-substituted 4-imidazolidinones by an isocyanide-based pseudo-five-multicomponent reaction
(Royal Society of Chemistry, 2018-11-01)
A pseudo-five-multicomponent reaction involving an isocyanide, a primary amine, two molecules of formaldehyde and water is reported, which gives N,N′-substituted 4-imidazolidinones when trifluoroethanol is used as the ...
Multicomponent reactions in the discovery of organocatalysts and the diversification of organocatalytic approaches
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2015-06-19)
This thesis reports the development of multicomponent approaches directed to specific objectives: a) the discovery of new and efficient peptide-based catalyst for asymmetric
transformations and b) the synthesis of ...
Synthesis and in vitro Antifungal Evaluation of Novel N-Substituted 4-Aryl-2-methylimidazoles
(Wiley-VCH, 2018-05)
An efficient and regioselective synthesis of novel 4-aryl-2-methyl-N-phenacylimidazoles 5 by a microwave-assisted pseudo-tricomponent reaction between acetamidine hydrochloride (3) and α-bromoacetophenones 2 has been ...
KBE009: An antimalarial bestatin-like inhibitor of the Plasmodium falciparum M1 aminopeptidase discovered in an Ugi multicomponent reaction-derived peptidomimetic library
(Pergamon-Elsevier Science Ltd, 2017)
Malaria is a global human parasitic disease mainly caused by the protozoon Plasmodium falciparum. Increased parasite resistance to current drugs determines the relevance of finding new treatments against new targets. A ...
Síntese de pseudo-peptídeos contendo calcogenonucleosídeos via reações de UGI como potenciais inibidores do SARS-CoV-2
(Universidade Federal de Santa MariaBrasilQuímicaUFSMPrograma de Pós-Graduação em QuímicaCentro de Ciências Naturais e Exatas, 2023-03-30)
In this work, a reaction protocol was developed for a new class of pseudo-peptides through multicomponent reactions (MCR) of the Ugi’s four component reaction (U-4CR) type, starting from chalcogenonucleosides. The synthetic ...
Síntesis de moléculas híbridas fluorofóricas y farmacofóricas vía reacciones de multicomponentes
(Universidad Michoacana de San Nicolás de Hidalgo, 2022-04)
In this thesis, two novel synthetic strategies to access pharmacophoric and flurophoric hybrid systems based on 1,5-disubstituted tetrazole and benzofuran moiety by using the high-order pseudo-multicomponent reaction and ...
Flow Chemistry: From assembly to the application
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2018-12-17)
Over the centuries, chemical reactions have been carried out in the same way in standardized glassware. On the other hand, continuous flow reactions are gaining interest regularly and demand for the related hardware toolkit ...