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Design of experiments (DoE) to develop and to optimize nanoparticles as drug delivery systems
(2021-08-01)
Nanotechnology has been widely applied to develop drug delivery systems to improve therapeutic performance. The effectiveness of these systems is intrinsically related to their physicochemical properties, so their biological ...
Estabelecimento de condições para ensaio de dissolução de cápsulas de cinarizina empregando planejamento fatorial
(Sociedade Brasileira de Química, 2011-01-01)
This work describes the establishment of dissolution test conditions for 75 mg cinnarizine capsules using a multivariate approach. A 2³ full factorial design was carried out to achieve the best conditions and HCl 0.1 mol ...
Estabelecimento de condições para ensaio de dissolução de cápsulas de cinarizina empregando planejamento fatorial
(Sociedade Brasileira de Química, 2011-01-01)
This work describes the establishment of dissolution test conditions for 75 mg cinnarizine capsules using a multivariate approach. A 2³ full factorial design was carried out to achieve the best conditions and HCl 0.1 mol ...
Application of full factorial design and Doehlert matrix for the optimisation of beef tallow methanolysis via homogeneous catalysis
(2011)
The transesterification of triglycerides by means of alkaline catalysts is the most widely used route for biodiesel
production and reaction optimisation by multivariate methods has been used for biodiesel production ...
Application of Factorial Design Experiments to the Development of a Disposable Amperometric DNA Biosensor
(Wiley-v C H Verlag Gmbh, 2011-11-01)
The development of an amperometric DNA-based biosensor (genosensor) requires the optimization of many experimental parameters in order to maximize sensitivity. If only one parameter is evaluated per experiment, the resultant ...
Application of Factorial Design Experiments to the Development of a Disposable Amperometric DNA Biosensor
(Wiley-v C H Verlag Gmbh, 2011-11-01)
The development of an amperometric DNA-based biosensor (genosensor) requires the optimization of many experimental parameters in order to maximize sensitivity. If only one parameter is evaluated per experiment, the resultant ...
Solid lipid nanoparticles optimized by 22 factorial design for skin administration: Cytotoxicity in NIH3T3 fibroblasts
(2018-11-01)
The present study focuses on the characterization of the cytotoxic profile on NIH3T3 mouse embryonic fibroblasts of solid lipid nanoparticles (SLN) optimized by a 22 full factorial design for skin administration. To build ...
Estabelecimento de condições para ensaio de dissolução de cápsulas de cinarizina empregando planejamento fatorial
(Sociedade Brasileira de Química, 2014)