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Tick salivary gland as potential natural source for the discovery of promising antitumor drug candidates
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)
Nowadays, the relationship between cancer blood coagulation is well established. Regarding biodiversity and bioprospection, the tick biology has become quite attractive natural source for coagulation inhibitors, since its ...
Selective Hypoxia-Cytotoxin 7-Fluoro-2-Aminophenazine 5,10-Dioxide: Toward Candidate-to-Drug Stage in the Drug-Development Pipeline
(Wiley Blackwell Publishing, Inc, 2019-08)
7-Fluoro-2-aminophenazine 5,10-dioxide, 1, has displayed in vitro bioreductive selective cytotoxicity, which could acts towards tumors containing hypoxic regions. In this work, we describe some preclinical studies of ...
Recent advances in the use of metallic nanoparticles with antitumoral action - Review
(2019-01-01)
The term cancer represents a set of more than 100 diseases that are caused due to an uncontrolled growth of cells; and their subsequent spread to the other tissues and organs of the body by a phenomenon, called ‘metastasis’. ...
Amblyomin-X induces ER stress, mitochondrial dysfunction, and caspase activation in human melanoma and pancreatic tumor cell
(Springer, 2016)
During the last two decades, new insights into proteasome function and its role in several human diseases made it a potential therapeutic target. In this context, Amblyomin-X is a Kunitz-type FXa inhibitor similar to ...
Cytotoxic and Antitumor Activity of some Coumarin Derivatives
(SAGE Publications, 2016-09)
Several natural and synthetic coumarins were assayed against different cancer cell lines. Four of them have shown cytotoxicity against a panel of three human solid tumor cell lines (HeLa, T-47D, and WiDr) and a clearly ...
Ru (II)–thyminate complexes new metallodrug candidates against tumor cells
(Royal Society of Chemistry, 2019)
Anti-tumor activities of peptides corresponding to conserved complementary determining regions from different immunoglobulins
(Elsevier B.V., 2014-09-01)
Short synthetic peptides corresponding to sequences of complementarity-determining regions (CDRs) from different immunoglobulin families have been shown to induce antimicrobial, antiviral and antitumor activities regardless ...
Planejamento, síntese e avaliação da atividade citotóxica de benzamidinas e arilguanidinas derivadas de carboidratos
(Universidade Federal de Minas GeraisUFMG, 2014-02-06)
Benzamidines and arylguanidines derivatives exhibit interesting antitumor activity from its intercalation with the DNA molecule. This may occur by ð-stacking interactions between aromatic rings of ligands and the bases ...
Synthesis, Spectroscopic Characterization, Structural Studies, and in Vitro Antitumor Activities of Pyridine-3-carbaldehyde Thiosemicarbazone Derivatives
(Hindawi, 2020)
Eight new thiosemicarbazone derivatives, 6-(1-trifluoroethoxy)pyridine-3-carbaldehyde thiosemicarbazone (1), 6-(4′-fluorophenyl)pyridine-3-carbaldehyde thiosemicarbazone (2), 5-chloro-pyridine-3-carbaldehyde thiosemicarbazone ...