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Preparation and Characterization of Poloxamer 407 Solid Dispersions as an Alternative Strategy to Improve Benznidazole Bioperformance
(Elsevier, 2018-11)
Benznidazole (BZL), the first line drug for Chagas disease treatment, presents a low solubility, limiting the possibilities for its formulation. In this work, solid dispersions’ (SDs) technology was exploited to increase ...
Improving furosemide polymorphs properties through supramolecular complexes of β-cyclodextrin
(Elsevier Science, 2014-03)
In this work, complexes of β-cyclodextrin and the two solid forms of furosemide were prepared and characterized for their potential pharmaceutical applications, with the interactions between the two compounds being studied ...
The Impact of Solid Dispersion on Formulation, Using Confocal Micro Raman Spectroscopy as Tool to Probe Distribution of Components
(Springer, 2018-03-16)
Purpose: Solid dispersions (SDs) of a poorly water-soluble drug were prepared, and their physicochemical properties were compared to those of control physical mixtures (PMs). Among the multiple techniques used to characterize ...
Chemical composition, antibacterial activity of essential oil Citrus sinensis l. (Sweet orange)and formulation of a pharmaceutical formComposición química, actividad antibacteriana del aceite esencial de Citrus sinensis L. (Naranja dulce) y formulación de una forma farmacéutica
(Universidad Nacional Mayor de San Marcos, Facultad de Farmacia y Bioquímica, 2010)
Furosemide:Triethanolamine Salt as a Strategy to Improve the Biopharmaceutical Properties and Photostability of the Drug
(American Chemical Society, 2019-04)
With the purpose of enhancing the biopharmaceutical properties of the furosemide, a pharmaceutical salt was obtained and characterized by combining the drug and triethanolamine. The solid system was prepared using different ...
Paclitaxel delivery system based on poly(lactide-co-glycolide) microparticles and chitosan thermo-sensitive gel for mammary adenocarcinoma treatment
(Pharmaceutical Press-Royal Pharmaceutical Society Great Britian, 2018-11)
Objectives: To evaluate the combination of more than one release system in the same formulation as a useful strategy to achieve paclitaxel delivery in a more sustained and controlled manner. Methods: The present study deals ...
Preparation and study of the antibacterial applications and oxidative stress induction of copper maleamate-functionalized mesoporous silica nanoparticles
(MDPI AG, 2019-01)
Mesoporous silica nanoparticles (MSNs) are an interesting class of nanomaterials with potential applications in different therapeutic areas and that have been extensively used as drug carriers in different fields of medicine. ...
Citrobacter koseri immobilized on agarose beads for nucleoside synthesis: a potential biocatalyst for preparative applications
(Springer, 2019-12)
The biocatalyzed synthesis of purine nucleosides and their analogs is a case widely studied due to the high pharmaceutical interest of these compounds, providing the whole-cell biocatalysts, a useful tool for this purpose. ...
Extemporaneous benznidazole oral suspension prepared from commercially available tablets for treatment of Chagas disease in paediatric patients
(Wiley Blackwell Publishing, Inc, 2015-07)
Objective: To develop an extemporaneous 1% benznidazole (BNZ) suspension, with masked taste and adequate stability starting from available commercial tablets. The quality of compounding was evaluated through content ...