Otro
Desenvolvimento e caracterização de nanocápsulas de poli(l-lactídeo) contendo benzocaína
Registro en:
Química Nova, v. 33, n. 1, p. 65-69, 2010.
0100-4042
ISSN0100-4042-2010-33-01-65-69.pdf
0000-0002-2042-018X
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Autor
Melo, Nathalie Ferreira Silva de
Grillo, Renato
Fraceto, Leonardo Fernandes
Dias Filho, Newton Luiz
Paula, Eneida de
Araújo, Daniele Ribeiro de
Rosa, André Henrique
Resumen
In this paper we describe the preparation poly (L-lactide) (PLA) nanocapsules as a drug delivery system for the local anesthetic benzocaine. The characterization and in vitro release properties of the system were investigated. The characterization results showed a polydispersity index of 0.14, an average diameter of 190.1± 3 nm, zeta potential of –38.5 mV and an entrapment efficiency of 73%. The release profile of Benzocaine loaded in PLA nanocapsules showed a significant different behavior than that of the pure anesthetic in solution. This study is important to characterize a drug release system using benzocaine for application in pain treatment.