dc.contributor | Universidade Estadual Paulista (UNESP) | |
dc.creator | Cicogna, Antonio Carlos | |
dc.creator | Robinson, Kathleen G. | |
dc.creator | Conrad, Chester H. | |
dc.creator | Squire, Robin | |
dc.creator | Okoshi, Marina Politi | |
dc.creator | Bing, Oscar H. L. | |
dc.date | 2014-05-27T11:18:18Z | |
dc.date | 2016-10-25T18:14:47Z | |
dc.date | 2014-05-27T11:18:18Z | |
dc.date | 2016-10-25T18:14:47Z | |
dc.date | 1997-12-01 | |
dc.date.accessioned | 2017-04-06T00:50:53Z | |
dc.date.available | 2017-04-06T00:50:53Z | |
dc.identifier | Arquivos Brasileiros de Cardiologia, v. 69, n. 6, p. 381-384, 1997. | |
dc.identifier | 0066-782X | |
dc.identifier | http://hdl.handle.net/11449/65289 | |
dc.identifier | http://acervodigital.unesp.br/handle/11449/65289 | |
dc.identifier | 10.1590/S0066-782X1997001200003 | |
dc.identifier | S0066-782X1997001200003 | |
dc.identifier | 2-s2.0-0031321453.pdf | |
dc.identifier | 2-s2.0-0031321453 | |
dc.identifier | http://dx.doi.org/10.1590/S0066-782X1997001200003 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/887025 | |
dc.description | Purpose - To investigate the participation of contractile state and relaxation in cardiac muscle dysfunction during the transition from stable hypertrophy to cardiac decompensation in aging spontaneously hypertensive rats (SHR). Methods - isolated left ventricular papillary muscle function was studied in SHR with heart failure (SHR-F), in age-matched SHR without evidence of heart failure (SHR-NF), and in nonhypertensive controls Wistar-Kyoto rats (WKY). Muscles were analised in isometric and isotonic contractions in Krebs-Henseleit solution with calcium concentration of 1.25mM at 28°C. Results - Papillary muscles from SHR-F and SHR-NF demonstrated decreased active tension development and shortening velocity relative to normotensive WKY (p<0.05). SHR-F and SHR-NF did not differ. Compared with SHR-NF and WKY, muscle passive stiffness was increased in the failing SHR (p<0.05 versus WKY and SHR-NF). This parameter did not differ between SHR-NF and WKY (p> 0.05). Conclusion - These data suggest that the progression from stable hypertrophy to heart failure is associated with changes in the passive stiffness and is not related to depression of myocardial contractile function. | |
dc.language | por | |
dc.relation | Arquivos Brasileiros de Cardiologia | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Heart failure | |
dc.subject | Hypertrophy | |
dc.subject | Myocardial function | |
dc.subject | animal | |
dc.subject | comparative study | |
dc.subject | forward heart failure | |
dc.subject | heart contraction | |
dc.subject | heart left ventricle function | |
dc.subject | heart left ventricle hypertrophy | |
dc.subject | heart right ventricle hypertrophy | |
dc.subject | hypertension | |
dc.subject | male | |
dc.subject | pathophysiology | |
dc.subject | physiology | |
dc.subject | rat | |
dc.subject | Wistar Kyoto rat | |
dc.subject | Animals | |
dc.subject | Cardiac Output, Low | |
dc.subject | Hypertension | |
dc.subject | Hypertrophy, Left Ventricular | |
dc.subject | Hypertrophy, Right Ventricular | |
dc.subject | Male | |
dc.subject | Myocardial Contraction | |
dc.subject | Rats | |
dc.subject | Rats, Inbred WKY | |
dc.subject | Ventricular Dysfunction, Left | |
dc.title | Participação do Estado Contrátil e do Relaxamento Miocárdico na Disfunção Ventricular durante a Transição Hipertrofia-Falência Cardíaca | |
dc.type | Otro | |