dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCicogna, Antonio Carlos
dc.creatorRobinson, Kathleen G.
dc.creatorConrad, Chester H.
dc.creatorSquire, Robin
dc.creatorOkoshi, Marina Politi
dc.creatorBing, Oscar H. L.
dc.date2014-05-27T11:18:18Z
dc.date2016-10-25T18:14:47Z
dc.date2014-05-27T11:18:18Z
dc.date2016-10-25T18:14:47Z
dc.date1997-12-01
dc.date.accessioned2017-04-06T00:50:53Z
dc.date.available2017-04-06T00:50:53Z
dc.identifierArquivos Brasileiros de Cardiologia, v. 69, n. 6, p. 381-384, 1997.
dc.identifier0066-782X
dc.identifierhttp://hdl.handle.net/11449/65289
dc.identifierhttp://acervodigital.unesp.br/handle/11449/65289
dc.identifier10.1590/S0066-782X1997001200003
dc.identifierS0066-782X1997001200003
dc.identifier2-s2.0-0031321453.pdf
dc.identifier2-s2.0-0031321453
dc.identifierhttp://dx.doi.org/10.1590/S0066-782X1997001200003
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/887025
dc.descriptionPurpose - To investigate the participation of contractile state and relaxation in cardiac muscle dysfunction during the transition from stable hypertrophy to cardiac decompensation in aging spontaneously hypertensive rats (SHR). Methods - isolated left ventricular papillary muscle function was studied in SHR with heart failure (SHR-F), in age-matched SHR without evidence of heart failure (SHR-NF), and in nonhypertensive controls Wistar-Kyoto rats (WKY). Muscles were analised in isometric and isotonic contractions in Krebs-Henseleit solution with calcium concentration of 1.25mM at 28°C. Results - Papillary muscles from SHR-F and SHR-NF demonstrated decreased active tension development and shortening velocity relative to normotensive WKY (p<0.05). SHR-F and SHR-NF did not differ. Compared with SHR-NF and WKY, muscle passive stiffness was increased in the failing SHR (p<0.05 versus WKY and SHR-NF). This parameter did not differ between SHR-NF and WKY (p> 0.05). Conclusion - These data suggest that the progression from stable hypertrophy to heart failure is associated with changes in the passive stiffness and is not related to depression of myocardial contractile function.
dc.languagepor
dc.relationArquivos Brasileiros de Cardiologia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHeart failure
dc.subjectHypertrophy
dc.subjectMyocardial function
dc.subjectanimal
dc.subjectcomparative study
dc.subjectforward heart failure
dc.subjectheart contraction
dc.subjectheart left ventricle function
dc.subjectheart left ventricle hypertrophy
dc.subjectheart right ventricle hypertrophy
dc.subjecthypertension
dc.subjectmale
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectrat
dc.subjectWistar Kyoto rat
dc.subjectAnimals
dc.subjectCardiac Output, Low
dc.subjectHypertension
dc.subjectHypertrophy, Left Ventricular
dc.subjectHypertrophy, Right Ventricular
dc.subjectMale
dc.subjectMyocardial Contraction
dc.subjectRats
dc.subjectRats, Inbred WKY
dc.subjectVentricular Dysfunction, Left
dc.titleParticipação do Estado Contrátil e do Relaxamento Miocárdico na Disfunção Ventricular durante a Transição Hipertrofia-Falência Cardíaca
dc.typeOtro


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