| dc.contributor | Universidade Estadual Paulista (UNESP) | |
| dc.creator | Castardeli, Edson | |
| dc.creator | Duarte, Daniella R. | |
| dc.creator | Minicucci, Marcos Ferreira | |
| dc.creator | Gaiolla, Paula Schmidt Azevedo | |
| dc.creator | Matsubara, Beatriz Bojikian | |
| dc.creator | Matsubara, Luiz Shiguero | |
| dc.creator | Campana, Alvaro O. | |
| dc.creator | Paiva, Sergio Alberto Rupp de | |
| dc.creator | Zornoff, Leonardo Antonio Mamede | |
| dc.date | 2014-05-20T13:33:22Z | |
| dc.date | 2016-10-25T16:51:27Z | |
| dc.date | 2014-05-20T13:33:22Z | |
| dc.date | 2016-10-25T16:51:27Z | |
| dc.date | 2008-03-01 | |
| dc.date.accessioned | 2017-04-05T20:23:41Z | |
| dc.date.available | 2017-04-05T20:23:41Z | |
| dc.identifier | Medical Science Monitor. Albertson: Int Scientific Literature, Inc, v. 14, n. 3, p. BR62-BR66, 2008. | |
| dc.identifier | 1234-1010 | |
| dc.identifier | http://hdl.handle.net/11449/11419 | |
| dc.identifier | http://acervodigital.unesp.br/handle/11449/11419 | |
| dc.identifier | WOS:000254101400004 | |
| dc.identifier | http://www.ncbi.nlm.nih.gov/pubmed/18301351 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/859189 | |
| dc.description | Background: We investigated the effects of length of exposure to tobacco smoke on the cardiac remodeling process induced by exposure to cigarette smoke in rats.Material/Methods: Rats were separated into 4 groups: nonsmoking (NS) 2 (n=25; control animals not exposed to tobacco smoke for 2 months), smoking (S)2 (n=22; rats exposed to smoke from 40 cigarettes/d for 2 months), NS6 (n=18; control animals not exposed to tobacco smoke for 6 months), and S6 (n=25; rats exposed to smoke from 40 cigarettes/d for 6 months). All animals underwent echocardiographic, isolated heart, and morphometric studies. Data were analyzed with a 2-way analysis of variance.Results: No interaction among the variables was found; this suggests that length of exposure to tobacco smoke did not influence the effects of exposure to smoke. Values for left ventricular diastolic diameter/body weight and left atrium/body weight were higher (p=0.023 and p=0.001, respectively) in smoking (S2 and S6) than in nonsmoking animals (NS2 and NS6). Left ventricular mass index was higher (p=0.048) in smoking than in nonsmoking animals. In the isovolumetrically beating ventricle, peak systolic pressure was higher (p=0.034) in smoking than in nonsmoking animals. Significantly higher values were found for left ventricular weight (p=0.017) and right ventricular weight (p=0.001) adjusted for body weight in smoking as opposed to nonsmoking animals. Systolic pressure was higher (p=0.001) in smoking (128 +/- 14 mm Hg) than in nonsmoking animals (112 +/- 11 mm Hg).Conclusions: Length of exposure to cigarette smoke did not influence cardiac remodeling caused by exposure to sm oke in rats. | |
| dc.language | eng | |
| dc.publisher | Int Scientific Literature, Inc | |
| dc.relation | Medical Science Monitor | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | ventricular function | |
| dc.subject | fibrosis | |
| dc.subject | ventricular dilatation | |
| dc.title | Exposure time and ventricular remodeling induced by tobacco smoke exposure in rats | |
| dc.type | Otro | |
