Otro
Anemia falciforme: desafios e avanços na busca de novos fármacos
Registro en:
Química Nova. Sociedade Brasileira de Química, v. 35, n. 4, p. 783-790, 2012.
0100-4042
10.1590/S0100-40422012000400025
S0100-40422012000400025
WOS:000304226400025
S0100-40422012000400025.pdf
Autor
Santos, Jean Leandro dos
Chin, Chung Man
Resumen
Sickle Cell Disease (SCD) is a disease characterized by a punctual mutation (GTG - GAG) in the sixth codon of the gamma globin gene leading to a substitution of glutamic acid by a valine in the β chain of hemoglobin. Despite the huge progress on the molecular knowledge of the disease in recent years, few therapeutic resources were developed. Currently, the treatment is mainly done with the anticancer agent hydroxyurea. This review summarizes current knowledge about possible targets and new approaches to the discovery new compounds to treat the symptoms of SCD. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)