Otro
Nitric oxide release using natural rubber latex as matrix
Registro en:
Materials Research. ABM, ABC, ABPol, v. 14, n. 3, p. 355-359, 2011.
1516-1439
10.1590/S1516-14392011005000055
S1516-14392011000300012
WOS:000296277000012
S1516-14392011000300012.pdf
0000-0003-0162-8273
Autor
Herculano, Rondinelli Donizetti
Tzu, Lee Chen
Silva, Cecilia Pereira
Brunello, Carlos Alberto
Queiroz, Álvaro Antônio Alencar de
Kinoshita, Angela
Graeff, Carlos Frederico de Oliveira
Resumen
Nitric oxide (NO) is a diffusible messenger that has been involved in numerous physiological processes ranging from vasodilatation and antimicrobial properties to wound healing. The beneficial effects can be attributed to the role NO plays in angiogenesis, inflammation and tissue remodeling. In the present work, a polymeric device for the sustained site specific delivery of nitric oxide using a latex rubber matrix from Hevea brasiliensis which encapsulates the spin trap iron(II)- diethyldithiocarbamate complex (FeDETC) was developed. The release profiles of NO from latex rubber matrix were studied and stability studies were carried out. Electron Paramagnetic Resonance (EPR) signal of NO was detected in the membrane exposed to ambient atmosphere at room temperature (25 °C) even after 350 hours. FTIR spectroscopy data indicated that NO-FeDETC retained its structural and spectroscopic properties upon encapsulation in the latex matrix. The NO delivery system developed in this work as a membrane, presented high stability. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)