Neurodevelopmental risk factors in schizophrenia

dc.creatorLobato, Maria Inês Rodrigues
dc.creatorBelmonte-de-Abreu, Paulo Silva
dc.creatorKnijnik, Daniela Zippin
dc.creatorTeruchkin, Betina
dc.creatorGhisolfi, Eduardo Sorensen
dc.creatorHenriques, Alexandre Annes
dc.date2010-04-24T04:15:29Z
dc.date2001
dc.identifier0100-879X
dc.identifierhttp://hdl.handle.net/10183/21145
dc.identifier000284412
dc.descriptionThe authors review environmental and neurodevelopmental risk factors for schizophrenic disorders, with emphasis on minor physical anomalies, particularly craniofacial anomalies and dermatoglyphic variations. The high prevalence of these anomalies among schizophrenic subjects supports the neurodevelopmental theory of the etiology of schizophrenia, since they suggest either genetically or epigenetically controlled faulty embryonic development of structures of ectodermal origin like brain and skin. This may disturb neurodevelopment that in turn may cause these subjects to be at increased risk for the development of schizophrenia and related disorders. The precise confirmation of this theory, at least in some cases, will provide further understanding of these illnesses, allowing easy and inexpensive identification of subjects at risk and providing guidelines for the development of new pharmacological interventions for early treatment and even for primary prevention of the illness.
dc.formatapplication/pdf
dc.languageeng
dc.relationBrazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 34, no. 2 (Feb. 2001), p. 155-163
dc.rightsOpen Access
dc.subjectSchizophrenia
dc.subjectNeurodevelopmental disorder
dc.subjectRisk factors
dc.subjectEsquizofrenia
dc.subjectFatores de risco
dc.subjectCérebro
dc.subjectDeficiências do desenvolvimento
dc.titleNeurodevelopmental risk factors in schizophrenia
dc.typeArtigo de periódico
dc.typeNacional


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