Nitric Oxide: Oxygen Radical Interactions in Atherosclerosis

dc.creatorRUBBO,HOMERO
dc.creatorBATTHYANY,CARLOS
dc.creatorRADI,RAFAEL
dc.date2000-01-01
dc.date.accessioned2017-03-07T16:18:16Z
dc.date.available2017-03-07T16:18:16Z
dc.identifierhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000200017
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/399315
dc.descriptionAtherosclerosis is one of the most common diseases and the principal cause of death in western civilization. The pathogenesis of this disease can be explained on the basis of the oxidative-modification hypothesis, which proposes that low-density lipoprotein (LDL) oxidation represents a key early event. Nitric oxide (.NO) regulates critical lipid membrane and lipoprotein oxidation events by a) contributing to the formation of more potent secondary oxidants from superoxide (i.e.: peroxynitrite), and b) its antioxidant properties through termination reactions with lipid radicals to possibly less reactive secondary nitrogen-containing products (LONO, LOONO). Relative rates of production and steady state concentrations of superoxide and .NO and cellular sites of production will profoundly influence the expression of differential oxidant injury-enhancing and protective effects of .NO. Full understanding of the physiological roles of .NO, coupled with detailed insight into .NO regulation of oxygen radical-dependent reactions, will yield a more rational basis for intervention strategies directed toward oxidant-dependent atherogenic processes
dc.formattext/html
dc.languageen
dc.publisherSociedad de Biología de Chile
dc.sourceBiological Research v.33 n.2 2000
dc.subjectantioxidants
dc.subjectfree radicals
dc.subjectlipid oxidation
dc.subjectlow density lipoprotein oxidation
dc.subjectnitric oxide
dc.subjectperoxynitrite
dc.titleNitric Oxide: Oxygen Radical Interactions in Atherosclerosis
dc.typeArtículos de revistas


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