Artículos de revistas
Tomato (Lycopersicon esculentum) supplementation induces changes in cardiac miRNA expression, reduces oxidative stress and left ventricular mass, and improves diastolic function
Fecha
2015-11-19Registro en:
Nutrients, v. 7, n. 11, p. 9640-9649, 2015.
2072-6643
10.3390/nu7115493
2-s2.0-84947727132
2-s2.0-84947727132.pdf
1590971576309420
1109525021631011
0000-0003-3775-3797
Autor
Universidade Estadual Paulista (Unesp)
Institución
Resumen
The aim of this study was to evaluate the effects of tomato supplementation on the normal rat heart and the role of oxidative stress in this scenario. Male Wistar rats were assigned to two groups: a control group (C; n = 16), in which animals received a control diet + 0.5 mL of corn oil/kg body weight/day, and a tomato group (T; n = 16), in which animals received a control diet supplemented with tomato +0.5 mL of corn oil/kg body weight/day. After three months, morphological, functional, and biochemical analyses were performed. Animals supplemented with tomato had a smaller left atrium diameter and myocyte cross-sectional area (CSA) compared to the control group (C group: 474 (415–539); T group: 273 (258–297) µm2; p = 0.004). Diastolic function was improved in rats supplemented with tomato. In addition, lipid hydroperoxide was lower (C group: 267 ± 46.7; T group: 219 ± 23.0 nmol/g; p = 0.039) in the myocardium of rats supplemented with tomato. Tomato intake was also associated with up-regulation of miR-107 and miR-486 and down-regulation of miR-350 and miR-872. In conclusion, tomato supplementation induces changes in miRNA expression and reduces oxidative stress. In addition, these alterations may be responsible for CSA reduction and diastolic function improvement.