dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-08-26T19:22:37Z
dc.date.available2015-08-26T19:22:37Z
dc.date.created2015-08-26T19:22:37Z
dc.date.issued2015-04-01
dc.identifierActa Cirurgica Brasileira, v. 30, n. 4, p. 270-276, 2015.
dc.identifier0102-8650
dc.identifierhttp://hdl.handle.net/11449/127513
dc.identifier10.1590/S0102-865020150040000006
dc.identifierS0102-86502015000400270
dc.identifierS0102-86502015000400270.pdf
dc.identifier8223546475724058
dc.identifier0585723113037140
dc.description.abstractTo evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model. METHODS: Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups. RESULTS: The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups. CONCLUSION: Parecoxib resulted in renal protection in this experimental model.
dc.languageeng
dc.publisherSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.relationActa Cirurgica Brasileira
dc.relation0.933
dc.relation0,395
dc.rightsAcesso aberto
dc.sourceSciELO
dc.subjectParecoxib
dc.subjectIschemia
dc.subjectReperfusion
dc.subjectKidney
dc.subjectRats
dc.titleParecoxib reduces renal injury in an ischemia/reperfusion model in rats
dc.typeArtículos de revistas


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