dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2015-08-26T19:22:37Z | |
dc.date.available | 2015-08-26T19:22:37Z | |
dc.date.created | 2015-08-26T19:22:37Z | |
dc.date.issued | 2015-04-01 | |
dc.identifier | Acta Cirurgica Brasileira, v. 30, n. 4, p. 270-276, 2015. | |
dc.identifier | 0102-8650 | |
dc.identifier | http://hdl.handle.net/11449/127513 | |
dc.identifier | 10.1590/S0102-865020150040000006 | |
dc.identifier | S0102-86502015000400270 | |
dc.identifier | S0102-86502015000400270.pdf | |
dc.identifier | 8223546475724058 | |
dc.identifier | 0585723113037140 | |
dc.description.abstract | To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model. METHODS: Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups. RESULTS: The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups. CONCLUSION: Parecoxib resulted in renal protection in this experimental model. | |
dc.language | eng | |
dc.publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia | |
dc.relation | Acta Cirurgica Brasileira | |
dc.relation | 0.933 | |
dc.relation | 0,395 | |
dc.rights | Acesso aberto | |
dc.source | SciELO | |
dc.subject | Parecoxib | |
dc.subject | Ischemia | |
dc.subject | Reperfusion | |
dc.subject | Kidney | |
dc.subject | Rats | |
dc.title | Parecoxib reduces renal injury in an ischemia/reperfusion model in rats | |
dc.type | Artículos de revistas | |