Artículos de revistas
Genetic Diversity in the Modern Horse Illustrated from Genome-Wide SNP Data
PLoS ONE, v. 8, n. 1, 2013.
College of Veterinary Medicine
College of Veterinary Medicine and Biomedical Science
Swedish University of Agricultural Sciences
University of Kentucky
School of Veterinary Medicine
Universidade Estadual Paulista (UNESP)
Biotechnology Centre of Azores
Institute for Animal Breeding and Genetics
Faculty of Veterinary Medicine
Animal Health Trust
French National Institute for Agricultural Research-Animal Genetics and Integrative Biology Unit
Nihon Bioresource College
College of Agriculture, Food Science and Veterinary Medicine
Institute of Genetics
Breakthrough Breast Cancer Research Centre
Comparative Neuromuscular Diseases Laboratory
Agroscope Liebefeld-Posieux Research Station
Norwegian School of Veterinary Science
Animal DNA Diagnostics Ltd
Laboratory of Racing Chemistry
Horses were domesticated from the Eurasian steppes 5,000-6,000 years ago. Since then, the use of horses for transportation, warfare, and agriculture, as well as selection for desired traits and fitness, has resulted in diverse populations distributed across the world, many of which have become or are in the process of becoming formally organized into closed, breeding populations (breeds). This report describes the use of a genome-wide set of autosomal SNPs and 814 horses from 36 breeds to provide the first detailed description of equine breed diversity. FST calculations, parsimony, and distance analysis demonstrated relationships among the breeds that largely reflect geographic origins and known breed histories. Low levels of population divergence were observed between breeds that are relatively early on in the process of breed development, and between those with high levels of within-breed diversity, whether due to large population size, ongoing outcrossing, or large within-breed phenotypic diversity. Populations with low within-breed diversity included those which have experienced population bottlenecks, have been under intense selective pressure, or are closed populations with long breed histories. These results provide new insights into the relationships among and the diversity within breeds of horses. In addition these results will facilitate future genome-wide association studies and investigations into genomic targets of selection. © 2013 Petersen et al.
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