Validation of microbiological assay for determination of cefuroxime in injectable preparations

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:26:56Z
dc.date.available2014-05-27T11:26:56Z
dc.date.created2014-05-27T11:26:56Z
dc.date.issued2012-08-22
dc.identifierLatin American Journal of Pharmacy, v. 31, n. 5, p. 746-750, 2012.
dc.identifier0326-2383
dc.identifierhttp://hdl.handle.net/11449/73510
dc.identifier2-s2.0-84865083152
dc.description.abstractThe validation of a microbiological assay, applying agar diffusion method for determination of the active of cefuroxime in power for injection, is described. Using a strain of Micrococcus luteus ATCC 9341 as the test organism, cefuroxime was measured in concentrations ranging from 30.0 to 120.0 μg/mL. The method validation showed that it is linear (r = 0.9999), precise (relative standard deviation = 0.37%) and accurate (it measured the added quantities). Microbiological assay is satisfactory for quantitation of cefuroxime in powder for injection and the validity of the proposed bioassay, which is a simple and a useful alternative methodology for cefuroxime determination in routine quality control.
dc.languageeng
dc.relationLatin American Journal of Pharmacy
dc.relation0.401
dc.relation0,152
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectCefuroxime
dc.subjectCephalosporins
dc.subjectMicrobiological assay
dc.subjectQuality control
dc.subjectValidation
dc.subjectcefuroxime
dc.subjectagar diffusion
dc.subjectbacterial growth
dc.subjectbacterial strain
dc.subjectbacterium culture
dc.subjectcalibration
dc.subjectcorrelation coefficient
dc.subjectdrug determination
dc.subjectdrug purity
dc.subjectdrug structure
dc.subjectlimit of detection
dc.subjectlimit of quantitation
dc.subjectmicrobiology
dc.subjectMicrococcus luteus
dc.subjectquality control
dc.subjectvalidation study
dc.titleValidation of microbiological assay for determination of cefuroxime in injectable preparations
dc.typeArtículos de revistas


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