dc.contributor | Tufts University | |
dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Yonsei University | |
dc.date.accessioned | 2014-05-27T11:19:48Z | |
dc.date.available | 2014-05-27T11:19:48Z | |
dc.date.created | 2014-05-27T11:19:48Z | |
dc.date.issued | 1999-12-01 | |
dc.identifier | Asia Pacific Journal of Clinical Nutrition, v. 8, n. 2, p. 160-166, 1999. | |
dc.identifier | 0964-7058 | |
dc.identifier | http://hdl.handle.net/11449/65928 | |
dc.identifier | 10.1046/j.1440-6047.1999.00087.x | |
dc.identifier | 2-s2.0-24044515580 | |
dc.description.abstract | Carotenoid concentrations were measured in serum and in both non-cancerous and cancerous gastric mucosal tissues of Korean patients with gastric cancer (n = 18). Carotenoids in serum and gastric tissue were extracted with chloroform/methanol (2:1), and measured using reverse-phase high-performance liquid chromatography with a C30 column. Cryptoxanthin and β-carotene were the major carotenoids in the Korean blood and they had a median ratio of non-cancerous tissue/serum levels which was less than 1.0. No significant differences of Cryptoxanthin and β-carotene levels were found between non-cancerous and cancerous tissues. After incubation of β-carotene with gastric tissue, significantly higher levels of β-carotene breakdown products were produced in the homogenates of cancerous tissue when compared with non-cancerous tissue. Lutein, zeaxanthin and α-carotene were the minor carotenoid constituents in the blood and their median ratio of non-cancerous tissue/serum levels was greater than 1.0. Cancerous tissue had significantly lower levels of lutein, zeaxanthin and α-carotene than did non-cancerous tissue. It appears that the increased breakdown of β-carotene and cryptoxanthin in cancerous tissue can be compensated for by an increased uptake of circulating carotenoids by cancerous tissue, whereas lutein, zeaxanthin and α-carotene levels in cancerous tissue are not able to be maintained. | |
dc.language | eng | |
dc.relation | Asia Pacific Journal of Clinical Nutrition | |
dc.relation | 1.335 | |
dc.relation | 0,697 | |
dc.rights | Acesso restrito | |
dc.source | Scopus | |
dc.subject | β-carotene | |
dc.subject | Carotenoids | |
dc.subject | Cryptoxanthin | |
dc.subject | Gastric cancer | |
dc.subject | Korea | |
dc.subject | Lycopene | |
dc.subject | Mucosa | |
dc.subject | Serum | |
dc.title | Endogenous carotenoid concentrations in cancerous and non-cancerous tissues of gastric cancer patients in Korea | |
dc.type | Artículos de revistas | |