dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-20T13:35:29Z | |
dc.date.available | 2014-05-20T13:35:29Z | |
dc.date.created | 2014-05-20T13:35:29Z | |
dc.date.issued | 2008-10-01 | |
dc.identifier | Journal of Reproductive Immunology. Clare: Elsevier B.V., v. 79, n. 1, p. 79-84, 2008. | |
dc.identifier | 0165-0378 | |
dc.identifier | http://hdl.handle.net/11449/12213 | |
dc.identifier | 10.1016/j.jri.2008.08.001 | |
dc.identifier | WOS:000260989000011 | |
dc.identifier | 8499437381595614 | |
dc.identifier | 6486557387397806 | |
dc.identifier | 1884059321499759 | |
dc.identifier | 0000-0003-4074-252X | |
dc.description.abstract | Objectives: Platelets and transforming growth factor-beta(1) (TGF-beta(1)) are thought to be involved in the pathogenesis of preeclampsia. Our objectives were to determine plasma concentration of TGF-beta(1) in normotensive and preeclamptic women in the third trimester of pregnancy and to evaluate the correlation of TGF-beta(1) plasma levels with platelet count and agonist-induced aggregation capacity.Methods: Thirty-three women with preeclampsia were compared with 36 healthy women with uncomplicated pregnancies. Peripheral venous blood samples were obtained, and TGF-beta(1) plasma levels measured by an enzyme-linked immunoassay. Platelet aggregation was induced by the agonist agents adenosine diphosphate (ADP), collagen and epinephrine, and was determined in platelet-rich plasma by aggregometry.Results: Plasma concentrations of active TGF-beta(1) were significantly higher in preeclamptic women (10.41 +/- 2.07 ng/mL) compared with normotensive pregnant women (7.01 +/- 3.29 ng/mL). Platelet number and platelet agonist-induced aggregation percent were significantly lower in patients with precclampsia than in healthy pregnant women. A significant correlation was observed between TGF-beta(1) plasma levels and platelet agonist-induced aggregation percent as between plasma levels of TGF-beta(1) and platelet number in preeclamptic patients.Conclusion: The association between impairment in platelet responsiveness and higher levels of TGF-beta(1) in the plasma of patients with preeclampsia suggests that this cytokine may play a role in the pathophysiological events of preeclampsia that are dependent on platelet activation. (C) 2008 Elsevier B.V. All rights reserved. | |
dc.language | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation | Journal of Reproductive Immunology | |
dc.relation | 2.322 | |
dc.relation | 0,997 | |
dc.rights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | Platelets | |
dc.subject | TGF-beta(1) | |
dc.subject | Preeclampsia | |
dc.subject | Pregnancy | |
dc.title | Platelet aggregation and TGF-beta(1) plasma levels in pregnant women with preeclampsia | |
dc.type | Artículos de revistas | |