dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-20T13:24:55Z | |
dc.date.available | 2014-05-20T13:24:55Z | |
dc.date.created | 2014-05-20T13:24:55Z | |
dc.date.issued | 2009-06-01 | |
dc.identifier | Chromatographia. Wiesbaden: Vieweg, v. 69, p. 241-244, 2009. | |
dc.identifier | 0009-5893 | |
dc.identifier | http://hdl.handle.net/11449/7857 | |
dc.identifier | 10.1365/s10337-009-1004-4 | |
dc.identifier | WOS:000267330400022 | |
dc.description.abstract | The objective of the current study was to develop and subsequently validate a simple, sensitive and precise reversed-phase LC method for the determination of ciprofloxacin hydrochloride in ophthalmic solution form. The chromatographic separation of ciprofloxacin hydrochloride was achieved on a Symmetry Waters C(18) column using UV detection at 275 nm. The optimized mobile phase consisted of 2.5% acetic acid solution: methanol:acetonitrile (70:15:15, v/v/v). The proposed method provided linear responses within the concentration range 1.0-6.0 mu g mL(-1) for ciprofloxacin hydrochloride. Correlation coefficient (r) for the ciprofloxacin hydrochloride was 0.9994. The precision of the method was demonstrated using intra- and inter-day assay RSD% values which were less than 5% in all instances. No interference from any components of pharmaceutical dosage forms was observed. | |
dc.language | eng | |
dc.publisher | Vieweg | |
dc.relation | Chromatographia | |
dc.relation | 1.401 | |
dc.relation | 0,514 | |
dc.rights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | Column liquid chromatography | |
dc.subject | Ophthalmic solution | |
dc.subject | Fluoroquinolone | |
dc.subject | Ciprofloxacin | |
dc.title | LC Assay for Ciprofloxacin Hydrochloride Ophthalmic Solution | |
dc.type | Artículos de revistas | |