Artículo de revista
Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?
Fecha
2018Registro en:
Free Radical Biology and Medicine, Volumen 124,
18734596
08915849
10.1016/j.freeradbiomed.2018.05.084
Autor
Peña Oyarzún, Daniel
Bravo Sagua, Roberto
Díaz Vega, Alexis
Aleman, Larissa
Chiong Lay, Mario
García Nannig, Lorena
Bambs, Claudia
Troncoso, Rodrigo
Cifuentes, Mariana
Morselli, Eugenia
Ferreccio, Catterina
Quest, Andrew F. G.
Criollo Céspedes, Alfredo
Lavandero González, Sergio
Institución
Resumen
© 2018 Elsevier Inc. Non-communicable diseases (NCDs), also known as chronic diseases, are long-lasting conditions that affect millions of people around the world. Different factors contribute to their genesis and progression; however they share common features, which are critical for the development of novel therapeutic strategies. A persistently altered inflammatory response is typically observed in many NCDs together with redox imbalance. Additionally, dysregulated proteostasis, mainly derived as a consequence of compromised autophagy, is a common feature of several chronic diseases. In this review, we discuss the crosstalk among inflammation, autophagy and oxidative stress, and how they participate in the progression of chronic diseases such as cancer, cardiovascular diseases, obesity and type II diabetes mellitus.