Artículo de revista
Circulating gonadotropins and ovarian adiponectin system are modulated by acupuncture independently of sex steroid or β-adrenergic action in a female hyperandrogenic rat model of polycystic ovary syndrome
Fecha
2015Registro en:
Molecular and Cellular Endocrinology, Volumen 412,
18728057
03037207
10.1016/j.mce.2015.04.026
Autor
Maliqueo Yevilao, Manuel
Benrick, Anna
Alvi, Asif
Johansson, Julia
Sun, Miao
Labrie, Fernand
Ohlsson, Claes
Stener-Victorin, Elisabet
Institución
Resumen
© 2015 Elsevier Ireland Ltd. Acupuncture with combined manual and low-frequency electrical stimulation, or electroacupuncture (EA), reduces endocrine and reproductive dysfunction in women with polycystic ovary syndrome (PCOS), likely by modulating sympathetic nerve activity or sex steroid synthesis. To test this hypothesis, we induced PCOS in rats by prepubertal implantation of continuous-release letrozole pellets (200 μg/day) or vehicle. Six weeks later, rats were treated for 5-6 weeks with low-frequency EA 5 days/week, subcutaneous injection of 17β-estradiol (2.0 μg) every fourth day, or a β-adrenergic blocker (propranolol hydrochloride, 0.1 mg/kg) 5 days/week. Letrozole controls were handled without needle insertion or injected with sesame oil every fourth day. Estrous cyclicity, ovarian morphology, sex steroids, gonadotropins, insulin-like growth factor I, bone mineral density, and gene and protein expression in ovarian tissue were measured. Low-frequency EA induced estrous-cycle c