Artículos de revistas
Genetic variation on the BAT1-NFKBIL1-LTA region of major histocompatibility complex class III associates with periodontitis
Fecha
2014Registro en:
Infection and Immunity, Volumen 82, Issue 5, 2018, Pages 1939-1948
10985522
00199567
10.1128/IAI.01681-13
Autor
Elisa Kallio, K. A.
Marchesani, Marja
Vlachopoulou, Efthymia
Mäntylä, Päivi
Paju, Susanna
Buhlin, Kåre
Suominen, Anna L.
Contreras, Johanna
Knuuttila, Matti
Hernandez, Marcela
Huumonen, Sisko
Nieminen, Markku S.
Perola, Markus
Sinisalo, Juha
Lokki, Marja
Institución
Resumen
Periodontitis is a chronic inflammatory disease with a multifactorial etiology. We investigated whether human major histocompatibility complex (MHC) polymorphisms (6p21.3) are associated with periodontal parameters. Parogene 1 population samples (n=169) were analyzed with 13,245 single nucleotide polymorphisms (SNPs) of the MHC region. Eighteen selected SNPs (P ≤ 0.001) were replicated in Parogene 2 population samples (n=339) and the Health 2000 Survey (n=1,420). All subjects had a detailed clinical and radiographic oral health examination. Serum lymphotoxin-α (LTA) concentrations were measured in the Parogene populations, and the protein was detected in inflamed periodontal tissue. In the Parogene 1 population, 10 SNPs were associated with periodontal parameters. The strongest associations emerged from the parameters bleeding on probing (BOP) and a probing pocket depth (PPD) of ≥6 mm with the genes BAT1, NFKBIL1, and LTA. Six SNPs, rs11796, rs3130059, rs2239527, rs2071591, rs909253, a