Artículos de revistas
The dorsal diencephalic conduction system of zebrafish as a model of vertebrate brain lateralisation
Fecha
2004Registro en:
NeuroReport, Volumen 15, Issue 12, 2018, Pages 1843-1846
09594965
10.1097/00001756-200408260-00001
Autor
Concha, Miguel L.
Institución
Resumen
Lateralisation is an attractive and intriguing feature of the vertebrate CNS studied for decades in the different disciplines of the neurosciences. Due to the complexity of the phenomena and intrinsic limitations of the approaches used to date, it has been difficult to establish useful links between the different, and usually distant, levels of lateralisation e.g. between genetics, morphology, physiology and behaviour. Recently, the dorsal diencephalon of the teleost zebrafish has emerged as a valuable model to begin addressing this issue and as a result unravel the role of vertebrate CNS lateralisation. Zebrafish is a well-established genetic system that allows a 'bottom up' ('gene to behaviour') approach to the study of lateralisation. In fact, it is the single vertebrate system to date in which asymmetric gene expression in the brain has been directly linked to asymmetric morphology. Zebrafish offers several experimental advantages that allow the study of brain lateralisation using