Artículos de revistas
Enalapril and prednisone in children with nephrotic-range proteinuria
Fecha
2000Registro en:
Pediatric Nephrology, Volumen 14, Issue 12, 2018, Pages 1088-1091
0931041X
10.1007/s004679900244
Autor
Delucchi Bicocchi, María Angela
Cano Schuffeneger, Francisco
Rodriguez, E.
Wolff, E.
Gonzalez, X.
Cumsille, M. A.
Institución
Resumen
The effect of enalapril and low prednisone doses on the urinary protein electrophoretic pattern was studied in 13 pediatric patients with glomerular diseases and steroid-resistant nephrotic syndrome. Enalapril was administred at doses of 0.2-0.6 mg/kg per day for 24-84 months, and prednisone was introduced 2 months later in 11 patients at doses of 30 mg/m2 on alternate days. The urine protein electrophoretic pattern showed a reduction of 80% and 70% in the total protein and albumin, respectively, after enalapril. Total urinary protein decreased from 5.46 to 1.1 g/m2 per day (P<0.001). A marked change from a pattern of non-selective urinary protein loss to an albumin-selective proteinuria was observed. Mean total plasma proteins increased from 4.7 to 5.43 g/dl (P<0.001). Four patients became free of proteinuria 24 months after enalapril was started, but only 2 remained free of proteinuria at 48 months of follow-up. The other 11 patients had persistent albuminuria of between 0.5 and 2.6