Artículos de revistas
Buccal Dosage Forms: General Considerations for Pediatric Patients
Fecha
2017Registro en:
AAPS PharmSciTech, Volumen 18, Issue 2, 2018, Pages 273-282
15309932
10.1208/s12249-016-0567-2
Autor
Montero-Padilla, Soledad
Velaga, Sitaram
Morales, Javier O.
Institución
Resumen
© 2016, American Association of Pharmaceutical Scientists. The development of an appropriate dosage form for pediatric patients needs to take into account several aspects, since adult drug biodistribution differs from that of pediatrics. In recent years, buccal administration has become an attractive route, having different dosage forms under development including tablets, lozenges, films, and solutions among others. Furthermore, the buccal epithelium can allow quick access to systemic circulation, which could be used for a rapid onset of action. For pediatric patients, dosage forms to be placed in the oral cavity have higher requirements for palatability to increase acceptance and therapy compliance. Therefore, an understanding of the excipients required and their functions and properties needs to be particularly addressed. This review is focused on the differences and requirements relevant to buccal administration for pediatric patients (compared to adults) and how novel dosage forms