Artículos de revistas
Pharmacokinetics of a nitrofuran compound, nifurtimox, in healthy volunteers
Fecha
1989Registro en:
International Journal of Clinical Pharmacology Therapy and Toxicology, Volumen 27, Issue 9, 1989, Pages 454-457
01744879
Autor
Paulos, C.
Paredes, J.
Vasquez, I.
Thambo, S.
Arancibia, A.
Gonzalez-Martin, G.
Institución
Resumen
Nifurtimox disposition was evaluated in 7 healthy volunteers. Each subject received an oral dose of 15 mg/kg of nifurtimox and blood sample was obtained 11 h after the drug administration. We used an analytical method previously assessed in the literature. The pharmacokinetic analysis was carried out according to a one-compartment model and the most important parameters established were elimination half-life, distribution volume, and clearance. Serum concentrations were low in relation to the high doses administered. The low serum concentration is probably the result of a marked first pass effect.