Artículo de revista
THE EFFECT OF SULPHAMETHOXYPYRIDAZINE ON LIVER AND PLASMA LEVELS OF VITAMIN A IN RATS
Fecha
1977Registro en:
British Journal of Pharmacology, Volumen 60, Issue 2, 2018, Pages 181-183
14765381
00071188
10.1111/j.1476-5381.1977.tb07739.x
Autor
BRAVO, MARÍA E.
MONCKEBERG, MARÍA E.
URBINA, MARÍA E.
Institución
Resumen
Long‐acting sulphonamides are highly bound to plasma proteins; the present study deals with the effects of this binding property upon a vitamin A compound also transported by plasma proteins. Sulphamethoxypyridazine was administered in rats either orally or by intraperitoneal injection. A significant fall in plasma vitamin A level and an increase in hepatic vitamin A concentration were observed. These results suggest an interference by sulphamethoxypyridazine with the transport of vitamin A, either through competition between the drug and vitamin A for binding sites of plasma proteins, or through altered secretion of the vitamin from the liver. 1977 British Pharmacological Society